The incidence and prevalence of inherited epidermolysis bullosa (EB) in the US are approximately 19.6 per 1 million live births and 8.2 per 1 million, respectively, based on data from the National EB Registry.[4]Fine JD, Johnson LB, Suchindran C, et al. The epidemiology of inherited EB: findings within American, Canadian, and European study populations. In: Fine JD, Bauer EA, McGuire J, et al, eds. Epidermolysis bullosa: clinical, epidemiologic, and laboratory advances, and the findings of the National Epidermolysis Bullosa Registry. Baltimore, MD: Johns Hopkins University Press; 1999:101-113.[5]Pfendner E, Uitto J, Fine JD. Epidermolysis bullosa carrier frequencies in the US population. J Invest Dermatol. 2001;116:483-484.
http://www.ncbi.nlm.nih.gov/pubmed/11231335?tool=bestpractice.com
Similar rates have been reported elsewhere in the world, suggesting no significant global differences.[6]Petrof G, Papanikolaou M, Martinez AE, et al. The epidemiology of epidermolysis bullosa in England and Wales: data from the national epidermolysis bullosa database. Br J Dermatol. 2022 May;186(5):843-8.
http://www.ncbi.nlm.nih.gov/pubmed/34927719?tool=bestpractice.com
There is no sex or ethnic predilection for any EB type or subtype. Approximately 70% of all people with EB have EB simplex (EBS). Of these, about two-thirds have EBS localized (EBS-loc) involving almost exclusively the palms and soles.[7]So JY, Teng J. Epidermolysis Bullosa Simplex. In: Adam MP, Mirzaa GM, Pagon RA, et al., eds. GeneReviews (Internet). Seattle, (WA): University of Washington, Seattle; August 4, 2022.
https://www.ncbi.nlm.nih.gov/books/NBK1369