Complications

Complication
Timeframe
Likelihood
variable
high

Seen in 75% of patients.

Reflects direct tumor damage and surgical/radiation therapy morbidity.[47][49][53][67][68]

Treated by replacement therapy.

Growth hormone deficiency in children

variable
high

Seen in 75% of patients.

Reflects direct tumor damage and surgical/radiation therapy morbidity.[47][49][53][67][68]

Treated by replacement therapy.

Hypogonadism in men

variable
high

Seen in 70% of children, 50% of adults.

Reflects injury by tumor and surgical morbidity and as a consequence of radiation therapy.[47][67][68]

Treated by replacement therapy.

Diabetes insipidus

variable
high

Seen in 25% of patients.

Reflects direct tumor damage and surgical/radiation therapy morbidity.[47][67][68]

Treated by replacement therapy.

variable
high

Seen in 25% of patients.

Reflects direct tumor damage and surgical/radiation therapy morbidity.[47][49][53][67][68]

Treated by replacement therapy.

Central hypothyroidism

variable
medium

Seen in more than 80% of patients.

Reflects injury by tumor and surgical morbidity.[24][47][50][51]

Evaluation of vision loss

variable
low

Seen in 15% to 25% of patients.

Reflects direct tumor damage and surgical/radiation therapy morbidity.[14][34][47][66]

May manifest as hyperphagia resulting in obesity, and neurobehavioral abnormalities.

variable
low

Seen in 10% to 20% of patients.

Reflects injury by tumor and surgical morbidity.

Treatment with anticonvulsants is indicated.[69]

Overview of seizure disorder

variable
low

Seen in more than 35% of patients.

Reflects injury by tumor and surgical/radiation therapy morbidity.[51][68][70]

Includes short-term memory loss, personality change.

Rehabilitation should be considered, and regular monitoring and long-term follow-up are essential.[69]

variable
low

Seen in more than 25% of patients.

Reflects injury by tumor and surgical/radiation therapy morbidity.[64][68][70]

variable
low

Seen in approximately 20% of patients.

Increased risk reflects increased prevalence of risk factors (obesity, diabetes, and metabolic syndrome) associated with endocrine dysfunction.[70]

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