Differentials

Common

Benign positional paroxysmal vertigo (BPPV)

History

vertigo on rolling over in bed or looking up, which lasts for seconds

Exam

Dix-Hallpike test: diagnostic of BPPV, typically demonstrating nystagmus and symptoms that are delayed by about 15 seconds, peak in 20-30 seconds, and then decay with complete resolution of the episode of vertigo; supine lateral head turns: similar to the Dix-Hallpike maneuver, a positive test is noted when the patient experiences vertigo with nystagmus.

1st investigation
  • none:

    diagnosis usually made clinically with Dix-Hallpike test and supine lateral head turns

Other investigations
  • pure-tone audiogram:

    normal pattern

  • brain MRI:

    normal

    More

Meniere disease

History

spontaneous vertigo attacks (each lasting 20 minutes to 12 hours) with documented low- to mid-frequency sensorineural hearing loss in the affected ear before, during, or after one of the episodes of vertigo, with fluctuating aural symptoms (hearing loss, tinnitus, or ear fullness) in the affected ear

Exam

usually normal, Romberg’s test may be positive, may have horizontal and/or rotatory nystagmus which is suppressed by fixation

1st investigation
  • pure-tone audiogram:

    sensorineural hearing-loss pattern usually at low frequencies

Other investigations
  • electronystagmography:

    normal or unilateral reduction in function

  • electrocochleography:

    abnormal action potential:summating potential (AP:SP) ratio with abnormal tone burst amplitude measurements

    More
  • MRI of internal auditory meatus and brain:

    normal

    More

Vestibular neuritis

History

acute onset of vertigo with nausea and vomiting, lasting days but without hearing loss; single episodes frequently recur; symptoms exacerbated by changes in head position

Exam

acute episode: may be nystagmus to the affected side, head impulse test will be abnormal (due to loss of the vestibulo-ocular reflex); loss of balance; between episodes of vertigo exam may be normal

1st investigation
  • pure-tone audiogram:

    normal pattern

    More
Other investigations
  • MRI brain:

    normal

    More

Labyrinthitis

History

acute onset of vertigo with nausea and vomiting lasting days; associated hearing loss with or without tinnitus; may be a preceding history of acute otitis media

Exam

nystagmus is usually horizontal, and severity improves as the illness resolves; patients may have difficulty walking; unilateral sensorineural hearing loss demonstrated with Rinne and Weber tuning fork tests; ear exam may demonstrate evidence of acute otitis media (bulging, erythematous, or opaque tympanic membrane); postaural redness or swelling may occur if mastoiditis complicates the infection

1st investigation
  • pure-tone audiogram:

    unilateral sensorineural hearing-loss pattern; a conductive loss pattern may occur if acute otitis media is present

Other investigations
  • CT scan petrous temporal bones:

    may demonstrate evidence of middle-ear or mastoid opacification

    More
  • MRI of internal auditory meatus and brain:

    normal

    More

Vestibular migraine

History

personal history or family history of migraine; vertigo with or without headaches; symptoms variable including true episodic vertigo, movement-provoked disequilibrium, lightheadedness, symptoms similar to benign positional paroxysmal vertigo, photophobia, phonophobia, or other auras, or symptoms similar to Meniere disease; associated symptoms of nausea and fatigue; symptoms might last minutes to days

Exam

usually normal, may have positional nystagmus and positive Romberg test in acute attack[118]

1st investigation
  • pure-tone audiogram:

    normal pattern

Other investigations
  • MRI brain:

    normal

    More

Presyncope

History

variable depending on specific cause but may include generalized weakness, giddiness, headache, blurred vision, and diaphoresis; may be paresthesia, nausea, and vomiting; patients have a sensation of an impending loss of consciousness

Exam

vasovagal attack: hypotension and bradycardia during attack; cardiopulmonary disease: altered cardiac rhythm, murmurs, evidence of cardiac failure

1st investigation
  • ECG:

    may demonstrate arrhythmia, ischemic changes or signs of structural heart disease

Other investigations
  • echocardiogram:

    may be evidence of structural heart disease

  • cardiac or event monitoring:

    arrhythmia may be detected associated with symptomatic episodes

  • tilt-table testing:

    may demonstrate evidence of autonomic neuropathy if symptoms are provoked

Orthostatic hypotension

History

dizziness on standing from a lying or sitting position, episodes are usually transient, may be a history of hypotension, antihypertensive medication use, dehydration, autonomic dysfunction (e.g., with Parkinson disease, multiple system atrophy, diabetic autonomic neuropathy); if associated with autonomic dysfunction may also have dizziness when standing upright for prolonged periods, swimming, or running and may complain of feeling "spacey" or "foggy" without vertigo during exertion; may be a history of bariatric surgery

Exam

drop in systolic BP by 20 mmHg or diastolic BP by 10 mmHg within three minutes of standing from a lying position

1st investigation
  • none:

    diagnosis usually made clinically without further investigations

    More
Other investigations
  • tilt-table testing:

    demonstrates orthostatic fall in BP

Postural orthostatic tachycardia syndrome

History

dizziness and palpitations on standing from a lying or sitting position, episodes are usually transient; may be fatigue, nausea, presyncope or syncope, more common in women and girls between 12-50 years of age

Exam

increase in heart rate on standing (and with tilt table study) by 30 bpm or >120 bpm and associated postural symptoms; lack of orthostatic hypotension; absence of other conditions that may cause orthostatic hypotension, such as dehydration, a primary cardiac cause, an endocrine disorder, or a nervous system disorder[60]

1st investigation
  • tilt table study:

    confirms excessive postural tachycardia, excludes orthostatic hypotension

Other investigations

    Diabetes mellitus

    History

    most commonly occurs in people with a known history of diabetes mellitus; often dizziness may coincide with episodes of hypoglycemia where patient feels ill, clammy, generally weak; may be a preceding peripheral vestibular disorder and prolonged symptoms, particularly with associated peripheral neuropathy (associated numbness in feet and legs and history of painless injuries)

    Exam

    may be signs of peripheral neuropathy including numbness and presence of painless injuries

    1st investigation
    • blood glucose:

      low during attacks

      More
    Other investigations
    • serum HbA1c:

      elevated compared with nondiabetic levels, but result may be lower than expected

      More

    Alcohol

    History

    acute intoxication: patients report feeling "high," dizzy, and intoxicated

    Exam

    smell of alcohol on the breath, disorientation, abnormal gait

    1st investigation
    • blood alcohol level:

      may be elevated

    Other investigations
    • serum LFTs:

      gamma glutamyl transpeptidase, aspartate aminotransferase, alanine aminotransferase may be deranged

    Drugs

    History

    history of aminoglycoside antibiotics, cisplatin, or other drugs that may cause dizziness (e.g., antihypertensive or antiarrhythmic medication, diuretics, antipsychotic or antiparkinsonian medication, opioids, phosphodiesterase inhibitors, or anesthetic medication); may be hearing loss and tinnitus with aminoglycosides and cisplatin

    Exam

    may be orthostatic hypotension on exam if taking antihypertensive, antipsychotic or antiparkinsonian medication, opioids, or phosphodiesterase inhibitors

    1st investigation
    • clinical exam:

      the diagnosis is often made clinically from the history and physical findings

    Other investigations
    • serum drug levels of aminoglycoside:

      may be elevated

      More
    • urine drug-toxicity screen:

      elevated levels of drugs or their metabolites

    • blood drug-toxicity screen:

      elevated levels of drugs or their metabolites

    • pure-tone audiogram:

      may be a sensorineural hearing-loss pattern or normal

      More
    • m.1555A>G mutation screening:

      may be present

      More

    Coronavirus disease 2019 (COVID-19)

    History

    dizziness associated with a current or previous COVID-19 infection, typical symptoms are dry cough, fever, and dyspnea; other common symptoms include anorexia, myalgia, and sore throat; may be travel history to an affected area or close contact with a suspected or confirmed case in the 14 days prior to symptom onset

    Exam

    may have fever and/or dyspnea; patients with pneumonia or respiratory distress syndrome may have inspiratory crackles, rales, and/or bronchial breathing; patients with respiratory distress syndrome may have tachycardia, tachypnea, or cyanosis accompanying hypoxia

    1st investigation
    • real-time reverse transcription polymerase chain reaction (RT-PCR):

      positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA

      More
    Other investigations

      Uncommon

      Cholesteatoma

      History

      malodorous ear discharge and hearing loss, with or without tinnitus; less commonly vertigo, otalgia, altered taste, or facial weakness

      Exam

      otoscopy reveals crust or keratin in the attic (upper part of the middle ear), the pars flaccida, or the pars tensa (usually posterior superior aspect), with or without perforation of the tympanic membrane; fistula test may be positive

      1st investigation
      • pure-tone audiogram:

        normal, conductive, or mixed conductive/sensorineural hearing-loss pattern

      Other investigations
      • CT scan of the petrous temporal bones:

        opacification of the middle ear, ossicular erosion, and erosion of the scutum; may demonstrate mastoid, cochlear, semicircular canal, or intracranial involvement

        More

      Superior semicircular canal dehiscence

      History

      history of episodes of vertigo associated with sound or pressure such as coughing, sneezing, straining, or sudden loud noise and hyperacusis; a feeling of the affected ear being blocked; autophony; may be preceding history of trauma

      Exam

      upward and torsional nystagmus evoked by Tullio (loud noise) and Hennebert (altered middle-ear pressure) tests

      1st investigation
      • pure-tone audiogram:

        conductive hearing-loss pattern

      • CT scan petrous temporal bones:

        bony dehiscence of the superior semicircular canal on the affected side

        More
      • vestibular evoked myogenic potential:

        increased amplitude may be demonstrated

      Other investigations
      • acoustic reflexes:

        normal

        More

      Perilymphatic fistula

      History

      may have a history of surgery such as stapes surgery, head trauma or barotrauma; paroxysmal vertigo, imbalance, and hearing loss with or without tinnitus

      Exam

      may have a positive fistula test

      1st investigation
      • pure-tone audiogram:

        sensorineural hearing-loss pattern

      Other investigations
      • exploratory tympanotomy:

        fistula noted at the round or oval window

      Persistent postural-perceptual dizziness (PPPD)

      History

      Five diagnostic criteria must be satisfied to make the diagnosis: 1) History of dizziness, unsteadiness, or nonspinning vertigo on most days for ≥3 months. 2) Symptoms occurring without provocation but worse with upright posture, active or passive motion, or exposure to moving stimuli. 3) Precipitated by conditions that cause vertigo, neurologic or medical illness, or psychological distress. 4) Symptoms cause significant distress or functional impairment. 5) Symptoms not better explained by another disorder.

      Exam

      physical exam normal

      1st investigation
      • none:

        diagnosis made based on clinical criteria

        More
      Other investigations

        Posterior fossa tumor

        History

        typically unilateral hearing loss, dizziness, or vertigo and tinnitus

        Exam

        spontaneous nystagmus may be present

        1st investigation
        • pure-tone audiogram:

          unilateral sensorineural hearing-loss pattern

        • contrast-enhanced structural MRI internal auditory meatus and brain:

          space-occupying lesion in cerebellopontine angle

        Other investigations
        • electronystagmography:

          abnormal tracking and abnormal optokinetic nystagmus test

        Multiple sclerosis

        History

        vertigo as an initial symptom (5%) or at some point during their disease (50%); prolonged spontaneous attacks of vertigo may be similar to vestibular neuritis; variety of symptoms such as dizziness, diplopia, and altered gait

        Exam

        variety of neurologic findings, such as nystagmus, ataxia, and cranial nerve palsies

        1st investigation
        • pure-tone audiogram:

          sensorineural hearing-loss pattern

        • MRI brain and spinal cord:

          demyelinating lesions demonstrated

        Other investigations

          Posterior circulation stroke

          History

          sudden intense vertigo, nausea, and vomiting, dysarthria, unilateral limb weakness, headache, diplopia

          Exam

          nystagmus present and may be bilateral or vertical (suggesting a central cause), head impulse test is negative, patients usually cannot stand without support; patients may have gait and limb ataxia, facial numbness, Horner syndrome, diplopia

          1st investigation
          • Blood glucose:

            normal

            More
          • CT head without contrast:

            may demonstrate hemorrhage or large infarction

          • MRI brain:

            lesions demonstrating cerebellar infarction or hemorrhage

            More
          Other investigations

            Vertebrobasilar insufficiency

            History

            episodic vertigo lasting between 30 seconds and 15 minutes and typically starting after abruptly standing or turning the head; associated with diplopia, dysarthria, ataxia, drop attack, and clumsiness of the extremities; may have risk factors for stroke such as hypertension, hyperlipidemia, diabetes, smoking, or heart disease

            Exam

            usually normal

            1st investigation
            • MRI brain ± angiogram:

              may be lesions demonstrating areas of infarction; vascular occlusion of the cerebellar arteries may be demonstrated on angiography

            Other investigations

              Arnold-Chiari malformation type 1

              History

              occipital headache, dizziness, unsteadiness, and hearing loss, but may be asymptomatic[44]

              Exam

              may be downbeat nystagmus, most prominent on lateral gaze; positional testing may precipitate dizziness with downbeat nystagmus

              1st investigation
              • MRI brain/spine:

                craniocervical lesion

              Other investigations

                Wallenberg syndrome (Lateral medullary infarction)

                History

                double vision, abnormal balance, facial or limb numbness, prolonged vertigo lasting several days

                Exam

                abnormal eye movements; ipsilateral Horner syndrome; diplopia; ipsilateral limb ataxia; truncal ataxia; dysphagia and hoarseness; loss of pain and temperature sensation of the ipsilateral face and contralateral trunk

                1st investigation
                • Blood glucose:

                  normal

                  More
                • CT head without contrast:

                  may demonstrate hemorrhage or large infarction[86]

                • MRI brain ± angiogram:

                  occlusion of the ipsilateral vertebral artery may be demonstrated

                Other investigations

                  Trauma

                  History

                  history of head trauma (e.g., a fall, an assault, or a motor vehicle accident), vertigo, disequilibrium, tinnitus, pressure, headache, diplopia

                  Exam

                  evidence of fluid or blood in the middle ear, evidence of a temporal bone fracture (e.g., mastoid and periorbital ecchymosis, abnormal neurologic findings, cerebrospinal fluid otorrhea).

                  1st investigation
                  • CT scan petrous temporal bones:

                    temporal bone fracture demonstrated

                  Other investigations
                  • electronystagmography:

                    abnormal response of affected side

                  • caloric testing:

                    abnormal response of affected side

                  • MRI scan head:

                    intracranial pathology

                    More

                  Vertebral artery dissection

                  History

                  more likely to be a young adult or trauma patient; dizziness, headache, and neck pain; may be history of predisposing factors, such as hypertension, recent infection, connective tissue disorder (e.g., Ehlers-Danlos syndrome, Marfan syndrome, osteogenesis imperfecta, fibromuscular dysplasia)​

                  Exam

                  dysarthria, visual field deficits, ataxia

                  1st investigation
                  • MRI angiogram:

                    may demonstrate double lumen in artery, evidence of intramural hematoma or pseudoaneurysm

                  • CT angiogram:

                    may demonstrate double lumen in artery, evidence of intramural hematoma or pseudoaneurysm

                  Other investigations
                  • carotid ultrasound with color doppler:

                    may demonstrate arterial dissection​​

                    More

                  Paraneoplastic cerebellar degeneration

                  History

                  history of cancer of the ovary, breast, or lung, or history of Hodgkin lymphoma; dizziness, nausea and vomiting, gait instability, altered speech, and dysphagia

                  Exam

                  nystagmus, ocular dysmetria, abnormalities of pursuit, saccadic oscillations, and an ataxic gait ± features of the associated cancer

                  1st investigation
                  • MRI brain:

                    evidence of cerebellar degeneration

                    More
                  • CT scan brain:

                    evidence of cerebellar degeneration

                    More
                  • CT scan or MRI of body:

                    tumor demonstrated

                  Other investigations
                  • anti-Yo and anti-Tr autoantibodies:

                    positive

                    More
                  • biopsies of accessible lesions:

                    neoplasm detected

                    More

                  Idiopathic intracranial hypertension

                  History

                  often obese; headaches and transient episodes of poor vision; dizziness and tinnitus

                  Exam

                  papilledema on fundoscopy; some have bilateral 6th nerve palsy

                  1st investigation
                  • MRI brain:

                    slit-like ventricles demonstrated

                  • Visual field testing:

                    visual field defects; enlarged blind spot, inferonasal loss, other nerve fiber bundle defects, or constriction of the field

                  Other investigations
                  • lumbar puncture and measurement of cerebrospinal fluid (CSF) pressure:

                    CSF pressure elevated

                    More

                  Normal pressure hydrocephalus

                  History

                  history of abnormal balance, urinary incontinence, and cognitive dysfunction

                  Exam

                  ataxic gait, cognitive dysfunction

                  1st investigation
                  • MRI brain:

                    normal

                  Other investigations
                  • lumbar puncture and measurement of cerebrospinal fluid (CSF) pressure:

                    normal CSF pressure

                    More
                  • cisternography:

                    no blockage of the cerebral aqueduct or of CSF outflow from the fourth ventricle

                  Mal de debarquement syndrome

                  History

                  swinging, swaying, unsteadiness, and disequilibrium after exposure to motion (e.g., long voyage, air travel); symptoms may last for hours, months, or years; symptoms occur after disembarking; not associated with nausea or vomiting

                  Exam

                  usually normal

                  1st investigation
                  • pure-tone audiogram:

                    normal pattern

                  Other investigations
                  • electronystagmography:

                    normal

                    More

                  Psychophysiological dizziness

                  History

                  a variety of symptoms such as rocking, floating, or swimming sensations; symptoms may worsen with stress or fatigue

                  Exam

                  anxious, may be hyperventilating, normal clinical balance tests

                  1st investigation
                  • hospital anxiety and depression scale:

                    may be abnormally high (>8)

                  Other investigations

                    Psychogenic dizziness

                    History

                    dizziness on standing and walking; may demonstrate anxiety reactions and avoidance behavior to specific stimuli; may be history of panic disorder with agoraphobia, personality disorders, or generalized anxiety; inappropriate or excessive anxiety or fear

                    Exam

                    normal clinical balance tests

                    1st investigation
                    • hospital anxiety and depression scale score:

                      abnormally high (>8)

                    Other investigations

                      Systemic lupus erythematosus (SLE)

                      History

                      history of SLE, photosensitive rash, fatigue, weight loss, alopecia, joint pain, symptoms of vertigo ± hearing loss

                      Exam

                      clinical features of SLE: malar rash, discoid rash, oral ulcers, hypertension, peripheral edema, retinal vasculitis

                      1st investigation
                      • antinuclear antibodies (ANA), anti-double-stranded DNA antibodies, anti-Smith antibodies:

                        ANA titre ≥1:80; anti-double-stranded DNA antibodies or anti-Smith antibodies positive[141]

                        More
                      Other investigations
                      • electronystagmography:

                        abnormal

                      • MRI brain:

                        may demonstrate white matter lesions or cerebral atrophy[148]

                        More

                      Cogan syndrome

                      History

                      history of photophobia, ocular discomfort, lacrimation, fluctuating hearing loss, imbalance or vertigo

                      Exam

                      ocular redness

                      1st investigation
                      • pure-tone audiogram:

                        sensorineural hearing-loss pattern

                        More
                      Other investigations
                      • slit-lamp exam:

                        may demonstrate features of interstitial keratitis, uveitis, episcleritis, or scleritis

                      • fluorescent treponemal antibodies absorption test:

                        negative

                        More

                      Granulomatosis with polyangiitis (formerly known as Wegener granulomatosis)

                      History

                      dizziness or vertigo, hearing loss, facial weakness; may have symptoms of nasal involvement with excessive nasal crusting, epistaxis or nasal discharge; lower respiratory tract symptoms of dyspnea, cough, hemoptysis or chest pain; fever, night sweats, anorexia, weight loss, malaise; neurologic symptoms of numbness, focal weakness or headache; ocular symptoms of redness, pain, diplopia, visual blurring; arthralgia, myalgia or joint swelling; purpuric, nodular, hemorrhagic or ulcerative skin lesions

                      Exam

                      serous otitis media (tympanic membrane retracted or concave, with impaired mobility), facial palsy, nasal lesions or upper respiratory tract mucosal bleeding, ulceration or crusting; may have septal perforation or saddle nose deformity; may have crackles, focal dullness to percussion or rhonchi; fever; mononeuritis multiplex; red eye, proptosis, reduced visual acuity, retinal exudates and hemorrhage; palpable purpura, cutaneous nodules, hemorrhagic and ulcerative skin lesions; joint tenderness or swelling, muscle weakness

                      1st investigation
                      • antineutrophil cytoplasmic antibody (ANCA):

                        positive

                      Other investigations
                      • biopsy of lesions for histology:

                        granulomatous inflammation, necrosis and vasculitis; minimal/absent immune deposits on immunofluorescence and electron microscopy

                      • Urinalysis and urine microscopy:

                        may show hematuria, proteinuria; dysmorphic red blood cells, RBC casts

                        More
                      • CT chest:

                        lung nodules (which may cavitate); infiltrates

                        More

                      Behcet disease

                      History

                      recurrent genital and oral ulceration, eye pain, photophobia, blurred vision, headache, hearing impairment, tinnitus, dizziness

                      Exam

                      genital ulcers, oral ulcers, red eye, acne lesions, erythema nodosum, superficial thrombophlebitis

                      1st investigation
                      • none:

                        diagnosis is based on clinical criteria[151]

                      Other investigations

                        Carbon monoxide poisoning

                        History

                        may be history of suspected accidental exposure from residential boilers, central heating systems, cookers, fireplaces, and chimneys; often nonspecific symptoms, such as vertigo, headaches, impaired concentration, presyncope, angina, shortness of breath, nausea and vomiting, fatigue[108]

                        Exam

                        may be normal; flushed cheeks, tachycardia, hypotension

                        1st investigation
                        • carboxyhemoglobin level:

                          elevated

                        Other investigations
                        • chest x-ray:

                          may be signs of noncardiogenic pulmonary edema

                        • ECG:

                          may be tachycardia, arrhythmias, features of cardiac ischemia

                        • blood glucose:

                          may be elevated

                        • lactate:

                          may be elevated in severe poisoning

                        • cardiac biomarkers:

                          may be elevated

                        Postsurgery

                        History

                        history of a surgical procedure (e.g., stapedectomy, middle-ear surgery, or cochlear implantation)

                        Exam

                        positive fistula test

                        1st investigation
                        • pure-tone audiogram:

                          elevated hearing thresholds or severe-to-profound hearing-loss pattern

                          More
                        Other investigations
                        • exploratory tympanotomy:

                          perilymphatic fistula may be present at the round or oval window

                          More

                        Secondary syphilis

                        History

                        hearing loss or vertigo with or without other variable symptoms (e.g., malaise, myalgia, rash); late neurosyphilis: may present with hearing loss, fluctuating hearing, or dizziness or vertigo with or without other variable symptoms (e.g., personality change, altered mood, loss of anal and bladder sphincter control)

                        Exam

                        variable signs, including lymphadenopathy, rash, mucosal ulceration with or without signs of more specific organ involvement (e.g., uveitis, meningism, seizures, nephrotic syndrome); late neurosyphilis: signs of tabes dorsalis (e.g., ataxia, Argyll-Robertson pupils, areflexia, loss of vibration/proprioception, positive Romberg sign), may have signs of memory impairment, confusion, tremor

                        1st investigation
                        • treponemal-specific serology:

                          positive

                          More
                        • nontreponemal serology:

                          positive

                          More
                        • pure-tone audiogram:

                          sensorineural hearing-loss pattern

                        Other investigations
                        • caloric test:

                          abnormal

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