Criteria
G6PD deficiency WHO working group[1]
Deficient activity of the enzyme usually results from structural mutations that reduce the stability of the enzyme. More than 400 variant enzymes have been characterized according to biochemical and physicochemical properties. These variants have been classified into 5 groups based on enzyme activity and clinical manifestations:
Class I: severely deficient, associated with chronic nonspherocytic hemolytic anemia
Class II: severely deficient (1%-10% residual activity), associated with acute hemolytic anemia
Class III: moderately deficient (10%-60% residual activity)
Class IV: normal activity (60%-150%)
Class V: increased activity (>150%).
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