Deposition of bilirubin in the basal ganglia of the neonate. Avoided by monitoring bilirubin levels closely and instituting phototherapy/exchange transfusion appropriately.
long term
high
Some studies have found increased incidence or earlier onset of cataracts in people with G6PD deficiency.[11]Luzzatto L, Vincenzo P: Glucose-6-phosphate dehydrogenase deficiency. In: Orkin SH et al, eds: Nathan and Oski's Hematology and oncology of infancy and childhood. Philadelphia, PA: Saunders; 2015:609-29.[12]Beutler E. G6PD deficiency. Blood. 1994 Dec 1;84(11):3613-36.
https://ashpublications.org/blood/article/84/11/3613/118679/G6PD-deficiency
http://www.ncbi.nlm.nih.gov/pubmed/7949118?tool=bestpractice.com
[21]Luzzatto L, Mehta AB, Vulliamy T. Glucose 6-phosphate dehydrogenase deficiency. In: Scriver CR, Beaudet AL, Sly WS, eds. The metabolic and molecular bases of inherited disease, 8th ed. New York, NY: McGraw Hill; 2001:4517-53.[37]Wan GH, Lin KK, Tsai SC, et al. Decreased glucose-6-phosphate dehydrogenase (G6PD) activity and risk of senile cataract in Taiwan. Ophthalmic Epidemiol. 2006 Apr;13(2):109-14.
http://www.ncbi.nlm.nih.gov/pubmed/16581614?tool=bestpractice.com
In vitro data, observations in neonates and trauma patients, and animal studies show possible increased susceptibility to infection.[48]Abu-Osba YK, Mallouh AA, Hann RW. Incidence and causes of sepsis in glucose-6-phosphate dehydrogenase deficient newborn infants. J Pediatr. 1989 May;114(5):748-52.
http://www.ncbi.nlm.nih.gov/pubmed/2715888?tool=bestpractice.com
[49]Abraham E. Glucose-6-phosphate dehydrogenase and sepsis:the jury is still out. Crit Care Med. 2007 Feb;35(2):655-6.
http://www.ncbi.nlm.nih.gov/pubmed/17251719?tool=bestpractice.com
This may be explained by the altered cytokine response and impaired neutrophil function in people with G6PD deficiency.[11]Luzzatto L, Vincenzo P: Glucose-6-phosphate dehydrogenase deficiency. In: Orkin SH et al, eds: Nathan and Oski's Hematology and oncology of infancy and childhood. Philadelphia, PA: Saunders; 2015:609-29.[21]Luzzatto L, Mehta AB, Vulliamy T. Glucose 6-phosphate dehydrogenase deficiency. In: Scriver CR, Beaudet AL, Sly WS, eds. The metabolic and molecular bases of inherited disease, 8th ed. New York, NY: McGraw Hill; 2001:4517-53.