Differentials
Dry eyes
SIGNS / SYMPTOMS
Typically a chronic condition of adults; occurs in women more than men; usually bilateral with minimal discharge or eyelash matting; minimal injection; no discharge or lymphadenopathy.
INVESTIGATIONS
Punctate staining of the cornea with fluorescein dye; Schirmer tests with <10 mm; tear break-up time <10 seconds.
Blepharitis
SIGNS / SYMPTOMS
Typically a chronic condition of adults; occurs in women more than men; usually bilateral with minimal discharge or eyelash matting; minimal injection; no discharge or lymphadenopathy; presence of meibomian gland dysfunction, eyelid margin telangiectatic vessels; collarets along the lashes.
INVESTIGATIONS
Tear break-up time <10 seconds.
Episcleritis
SIGNS / SYMPTOMS
Unilateral more common than bilateral; typically segmental injection; no discharge or eyelid matting; minimal discomfort.
INVESTIGATIONS
No definitive tests; recurrent, bilateral, or persistent cases require blood tests to rule out a systemic inflammatory disease.
Contact lens over-wear
SIGNS / SYMPTOMS
History of sleeping in contacts; multiple recurrences; light sensitivity.
INVESTIGATIONS
No definitive tests.
Anterior uveitis (iritis)
SIGNS / SYMPTOMS
Pain and light sensitivity more pronounced than irritation; unilateral more common than bilateral.
INVESTIGATIONS
No definitive tests; recurrent, bilateral, or persistent cases require blood tests to rule out a systemic inflammatory disease.
Red and white blood cells, as well as flare (effect caused by an increase in the protein content of the aqueous) usually seen with slit-lamp examination.
Acute angle-closure glaucoma
SIGNS / SYMPTOMS
Adult typically older than 40 years; nausea and vomiting may also be present as well as a deep, dull, periocular headache; unilateral; pain associated with decreased vision; mid-dilated, unreactive pupil; presence of an afferent pupillary defect.
INVESTIGATIONS
Marked elevation in intraocular pressure (normal <22 mmHg); thin corneas (pachymetry <520); afferent pupillary defect.
Keratitis
SIGNS / SYMPTOMS
Patient may report intense pain, discharge, photophobia, increased lacrimation; the eyelid may also swell.
Examination may reveal a corneal ulcer that may be bacterial, viral, or fungal; reduced visual acuity; a swollen eyelid and discharge may be visible.
Rarely, bacterial conjunctivitis can develop into keratitis in patients with a history of contact lens use or who are immunocompromised.
INVESTIGATIONS
An epithelial defect can be seen easily after staining the cornea with fluorescein.
Corneal scrape for microscopy culture and sensitivity: performed in a specialist clinic.
Corneal ulcer
SIGNS / SYMPTOMS
Patient may initially report a foreign body sensation, which progresses to photophobia, blurred vision, pain, and discharge; the eyelids may also swell.
Examination may reveal reduced visual acuity, often severe conjunctival injection; a swollen eyelid and discharge may be visible; corneal fluorescein stain seen; ulcer may be bacterial, viral, or fungal.
INVESTIGATIONS
Corneal scrape for microscopy culture and sensitivity: performed in a specialist clinic.
Ulcer may be bacterial, viral, or fungal in etiology.
Corneal abrasion
SIGNS / SYMPTOMS
Acute onset of ocular unease; this may have been preceded by a history of minor trauma.
Reduced visual acuity; normal pupillary reactions; single eye, conjunctival injection with corneal fluorescein stain seen; the eyelid may be swollen; no discharge.
INVESTIGATIONS
Corneal abrasion can be seen with fluorescein stain.
Corneal foreign body
SIGNS / SYMPTOMS
A foreign body sensation progressing to photophobia and pain may be reported; the sensation is frequently preceded by a gust of wind or following use of hammering or grinding equipment.
A foreign body may be seen either on the cornea, under the upper lid, or within the lower fornix; normal visual acuity and pupillary reactions.
INVESTIGATIONS
In cases of high-velocity injuries, imaging of the orbit is required to exclude an intraocular foreign body.
Subtarsal conjunctival foreign body
SIGNS / SYMPTOMS
Often reduced vision; small particle foreign body into eye, often wind-blown with low velocity; persistent sharp scratching foreign body sensation, worse on blinking; watering, often profuse; no discharge.
On examination, possible reduced visual acuity; injected conjunctiva, often localized; foreign body visible on conjunctiva on eversion of eyelid (either upper or lower), often best visualized with fluorescein staining; corresponding fine linear corneal abrasions; normal pupil response.
INVESTIGATIONS
Foreign body can be visualized with fluorescein staining.
Subconjunctival hemorrhage (nontraumatic)
SIGNS / SYMPTOMS
Usually appears spontaneously; occasionally history of Valsalva maneuver, coughing, sneezing, or heavy lifting; usually asymptomatic; occasional mild discomfort, or popping sensation at onset; possible association with systemic hypertension or anticoagulant medication.
Examination reveals well-circumscribed area of confluent hemorrhage underneath conjunctiva (if the posterior border cannot be seen then it may originate from intracranial hemorrhage, which warrants immediate emergency referral), often sectorial; cornea clear, no fluorescein stain; normal visual acuity and pupil response; possible systemic hypertension; blood pressure should be measured in all patients and managed as per guidelines.
INVESTIGATIONS
No definitive tests. Clinical diagnosis.
Scleritis
SIGNS / SYMPTOMS
Patient may report severe ocular pain and redness (prominent feature); no discharge; reduced visual acuity may be present; past medical history should be reviewed for any known systemic associations such as connective tissue disorders including rheumatoid arthritis, granulomatosis with polyangiitis (formerly known as Wegener granulomatosis), systemic lupus erythematosus, and relapsing polychondritis.
Examination may reveal deep scleral vessel engorgement and pain on ocular palpation; no fluorescein stain; visual acuity and pupillary reactions may be abnormal depending on the position of the scleritis on the globe (anterior or posterior).
INVESTIGATIONS
Evaluation for causes of scleritis should be performed in a specialist clinic to evaluate for underlying autoimmune disease.
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