Differentials

Sepsis

SIGNS / SYMPTOMS
INVESTIGATIONS
SIGNS / SYMPTOMS

Patients may present with fever and rigors. However, a lowered temperature is possible (particularly in very young patients and older adult patients) and the presentations may be indistinguishable.

INVESTIGATIONS

Blood and urine cultures and tracheal aspirate with Gram stain analysis may show a pathogen. WBC may be elevated.

Hypothyroidism

SIGNS / SYMPTOMS
INVESTIGATIONS
SIGNS / SYMPTOMS

Cases that mimic hypothermia most commonly result from longstanding hypothyroidism. Typical symptoms include cold intolerance, fatigue, weight gain, constipation, a deep voice, coarse hair, and dry skin.

Severe hypothyroidism may result in myxedema coma. Myxedema refers to nonpitting edema of skin and soft tissue. An associated change in level of consciousness (not necessarily coma) is present.

Concurrent infection or noncompliance with thyroid replacement medications may precipitate myxedema coma in a patient with hypothyroidism.

INVESTIGATIONS

Thyroid function tests show a high thyroid-stimulating hormone and low free thyroxine/triiodothyronine (T4/T3).

Hypoglycemia

SIGNS / SYMPTOMS
INVESTIGATIONS
SIGNS / SYMPTOMS

Common presenting symptoms include nausea, confusion, tremor, sweating, palpitations, or hunger.

Patients may present with a lowered temperature as hypoglycemia can impair the body’s ability to retain heat through shivering.

INVESTIGATIONS

Serum glucose <50 mg/dL (<2.8 mmol/L).

Substance misuse and overdose

SIGNS / SYMPTOMS
INVESTIGATIONS
SIGNS / SYMPTOMS

Substance misuse (e.g., with cannabis) may impair judgment and restrict shivering, thereby limiting the ability to respond appropriately to cold temperatures.

Signs and symptoms depend on the substance taken.

INVESTIGATIONS

Drug screen will be positive for substances taken.

Alcohol intoxication

SIGNS / SYMPTOMS
INVESTIGATIONS
SIGNS / SYMPTOMS

Usually presents with altered mental state alone. Alcohol causes vasodilation, impairs judgment, and causes somnolence and a subjective feeling of warmth. Measures to prevent hypothermia may not be taken and therefore patients may present with lowered temperatures.

INVESTIGATIONS

Serum alcohol level will be positive.

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