Differentials
Sepsis
SIGNS / SYMPTOMS
Patients may present with fever and rigors. However, a lowered temperature is possible (particularly in very young patients and older adult patients) and the presentations may be indistinguishable.
INVESTIGATIONS
Blood and urine cultures and tracheal aspirate with Gram stain analysis may show a pathogen. WBC may be elevated.
Hypothyroidism
SIGNS / SYMPTOMS
Cases that mimic hypothermia most commonly result from longstanding hypothyroidism. Typical symptoms include cold intolerance, fatigue, weight gain, constipation, a deep voice, coarse hair, and dry skin.
Severe hypothyroidism may result in myxedema coma. Myxedema refers to nonpitting edema of skin and soft tissue. An associated change in level of consciousness (not necessarily coma) is present.
Concurrent infection or noncompliance with thyroid replacement medications may precipitate myxedema coma in a patient with hypothyroidism.
INVESTIGATIONS
Thyroid function tests show a high thyroid-stimulating hormone and low free thyroxine/triiodothyronine (T4/T3).
Hypoglycemia
SIGNS / SYMPTOMS
Common presenting symptoms include nausea, confusion, tremor, sweating, palpitations, or hunger.
Patients may present with a lowered temperature as hypoglycemia can impair the body’s ability to retain heat through shivering.
INVESTIGATIONS
Serum glucose <50 mg/dL (<2.8 mmol/L).
Substance misuse and overdose
SIGNS / SYMPTOMS
Substance misuse (e.g., with cannabis) may impair judgment and restrict shivering, thereby limiting the ability to respond appropriately to cold temperatures.
Signs and symptoms depend on the substance taken.
INVESTIGATIONS
Drug screen will be positive for substances taken.
Alcohol intoxication
SIGNS / SYMPTOMS
Usually presents with altered mental state alone. Alcohol causes vasodilation, impairs judgment, and causes somnolence and a subjective feeling of warmth. Measures to prevent hypothermia may not be taken and therefore patients may present with lowered temperatures.
INVESTIGATIONS
Serum alcohol level will be positive.
Use of this content is subject to our disclaimer