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Last reviewed: 21 Mar 2025
Last updated: 13 Feb 2025

Summary

Definition

History and exam

Key diagnostic factors

  • cold exposure and body temperature <95°F (<35°C)
  • impaired mental status
  • shivering
  • frostbite

Other diagnostic factors

  • tachypnea, tachycardia, hypertension
  • respiratory depression, bradycardia, hypotension
  • coma and apnea
  • cold-induced diuresis

Risk factors

  • trauma
  • drowning
  • general anesthetic use
  • substance misuse
  • impaired cognition
  • hypothyroidism
  • stroke
  • Parkinson disease
  • homelessness
  • extremes of age
  • gram-negative septicemia
  • immobility
  • use of certain drugs

Diagnostic tests

1st tests to order

  • core temperature measurement
  • 12-lead ECG
  • CBC
  • serum electrolytes
  • blood glucose
  • ABG
  • clotting screen
  • chest x-ray

Tests to consider

  • serum creatinine kinase
  • myoglobin levels
  • end-tidal CO₂
  • ultrasound

Treatment algorithm

Contributors

Authors

Emmanuel Atta Agaba, MD, FRCSEd, FACS
Emmanuel Atta Agaba

Attending Surgeon

Assistant Professor of Surgery

Montefiore Medical Center at Albert Einstein College of Medicine

Bronx

NY

Disclosures

EAA declares that he has no competing interests.

Acknowledgements

Dr Emmanuel Agaba would like to gratefully acknowledge Dr Rafael Barrera and Dr Juan Jose Gilbert, previous contributors to this topic.

Disclosures

RB and JJG declare that they have no competing interests.

Peer reviewers

Wail Malaty, MD

Clinical Professor

Department of Family Medicine

University of North Carolina

Chapel Hill

Assistant Program Director

MAHEC Rural Family Medicine Residency

Hendersonville

NC

Disclosures

WM declares that he has no competing interests.

James S. Milledge, MBBS

Honorary Professor

Department of Physiology

University College London

London

UK

Disclosures

JSM declares that he has no competing interests.

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