Tests
Tests to consider
dermoscopy
Test
The characteristic dermoscopic features of seborrheic keratosis are milia-like cysts and comedo-like openings. Milia-like cysts are white or yellowish round structures that correspond to small intraepidermal, keratin-filled cysts (horn pearls). They are not exclusively found in seborrheic keratosis as they are also seen in congenital nevi and papillomatous dermal nevi but less frequently. Comedo-like openings (also called pseudofollicular openings or crypts) are brownish holes in the surface of seborrheic keratosis that correspond histologically to keratin-filled invaginations of the epidermis.[22][23][24]
Result
features of seborrheic keratosis
biopsy and histopathologic examination
Test
Sharply defined exophytic lesions growing intraepidermal proliferations composed of mature basaloid cells. The characteristic histologic features are keratin-filled invaginations and small cysts (horn cysts). Hyperkeratosis is present in variable degrees.
Result
features of seborrheic keratosis
reflectance confocal microscopy (RCM)
Test
RCM is a noninvasive imaging method that allows the in vivo examination of skin at cellular-level resolution. RCM features that indicate the diagnosis of seborrheic keratosis are: cerebriform surface structures; keratin-filled invaginations; corneal pseudocysts; a regular honeycomb pattern at epidermal layers; cords and polymorphous papillae at the dermo-epidermal junction; melanophages and looped vessels at the papillary dermis; and the absence of RCM features suggestive of malignancy.[25]
Result
features of seborrheic keratosis
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