General
If treated early, chances of renal recovery are quite good. Aggressive treatment with plasma exchange and immunosuppressive drugs leads to a one-year survival of approximately 87% in patients with Goodpasture disease.[37]Huart A, Josse AG, Chauveau D, et al. Outcomes of patients with Goodpasture syndrome: a nationwide cohort-based study from the French Society of Hemapheresis. J Autoimmun. 2016 Sep;73:24-9.
http://www.ncbi.nlm.nih.gov/pubmed/27267459?tool=bestpractice.com
If the disease has progressed to the point that the patient requires dialysis on admission to the hospital, the chances for renal recovery are <10%.[31]van Daalen EE, Jennette JC, McAdoo SP, et al. Predicting outcome in patients with anti-GBM glomerulonephritis. Clin J Am Soc Nephrol. 2018 Jan 6;13(1):63-72.
https://journals.lww.com/cjasn/fulltext/2018/01000/predicting_outcome_in_patients_with_anti_gbm.13.aspx
http://www.ncbi.nlm.nih.gov/pubmed/29162595?tool=bestpractice.com
[33]Levy JB, Turner AN, Rees AJ, et al. Long-term outcome of anti-glomerular basement membrane antibody disease treated with plasma exchange and immunosuppression. Ann Intern Med. 2001 Jun 5;134(11):1033-42.
http://www.ncbi.nlm.nih.gov/pubmed/11388816?tool=bestpractice.com
[34]Kant S, Kronbichler A, Sharma P, et al. Advances in understanding of pathogenesis and treatment of immune-mediated kidney disease: a review. Am J Kidney Dis. 2022 Apr;79(4):582-600.
https://www.doi.org/10.1053/j.ajkd.2021.07.019
http://www.ncbi.nlm.nih.gov/pubmed/34508831?tool=bestpractice.com
Relapse
There are case reports of relapse after initial successful treatment; however, the chances of recurrence are quite low.[1]Pusey CD. Anti-glomerular basement membrane disease. Kidney Int. 2003 Jul 7;64(7):1535-50.
http://www.ncbi.nlm.nih.gov/pubmed/12969182?tool=bestpractice.com
There is anecdotal evidence that relapse is more common in patients who have continued environmental exposure to cigarette smoking.[1]Pusey CD. Anti-glomerular basement membrane disease. Kidney Int. 2003 Jul 7;64(7):1535-50.
http://www.ncbi.nlm.nih.gov/pubmed/12969182?tool=bestpractice.com
Transplantation
Patients who develop end-stage renal disease may be considered for renal transplantation once the serum antiglomerular basement membrane (anti-GBM) antibody becomes undetectable.[1]Pusey CD. Anti-glomerular basement membrane disease. Kidney Int. 2003 Jul 7;64(7):1535-50.
http://www.ncbi.nlm.nih.gov/pubmed/12969182?tool=bestpractice.com