Case history

Case history #1

A 4-month-old child presents with faltering growth associated with persistent foul-smelling stools. A stool sample reveals steatorrhea. A blood test indicates absent low-density lipoprotein (LDL) cholesterol levels. Her parents are normocholesterolemic.

Case history #2

A gaunt 27-year-old woman presents with progressively worsening balance and movement, and deterioration of her vision. She reports habitually maintaining a low-fat diet to avoid diarrhea. Blood tests reveal absent LDL cholesterol levels, a prolonged partial thromboplastin time, and low blood tocopherol (vitamin E) levels.

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