Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy affecting the upper extremities.[1]Currie KB, Tadisina KK, Mackinnon SE. Common hand conditions: a review. JAMA. 2022 Jun 28;327(24):2434-45.
http://www.ncbi.nlm.nih.gov/pubmed/35762992?tool=bestpractice.com
It is more common in women than in men.[1]Currie KB, Tadisina KK, Mackinnon SE. Common hand conditions: a review. JAMA. 2022 Jun 28;327(24):2434-45.
http://www.ncbi.nlm.nih.gov/pubmed/35762992?tool=bestpractice.com
[2]Bongers FJ, Schellevis FG, van den Bosch WJ, et al. Carpal tunnel syndrome in general practice (1987 and 2001): incidence and the role of occupational and non-occupational factors. Br J Gen Pract. 2007 Jan;57(534):36-9.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2032698/?tool=pubmed
http://www.ncbi.nlm.nih.gov/pubmed/17244422?tool=bestpractice.com
[3]Padua L, Coraci D, Erra C, et al. Carpal tunnel syndrome: clinical features, diagnosis, and management. Lancet Neurol. 2016 Nov;15(12):1273-84.
http://www.ncbi.nlm.nih.gov/pubmed/27751557?tool=bestpractice.com
[4]Bland JD, Rudolfer SM. Clinical surveillance of carpal tunnel syndrome in two areas of the United Kingdom, 1991-2001. J Neurol Neurosurg Psychiatry. 2003 Dec;74(12):1674-9.
https://jnnp.bmj.com/content/74/12/1674.long
http://www.ncbi.nlm.nih.gov/pubmed/14638888?tool=bestpractice.com
The peak onset is usually between ages 40 and 60 years.[1]Currie KB, Tadisina KK, Mackinnon SE. Common hand conditions: a review. JAMA. 2022 Jun 28;327(24):2434-45.
http://www.ncbi.nlm.nih.gov/pubmed/35762992?tool=bestpractice.com
[2]Bongers FJ, Schellevis FG, van den Bosch WJ, et al. Carpal tunnel syndrome in general practice (1987 and 2001): incidence and the role of occupational and non-occupational factors. Br J Gen Pract. 2007 Jan;57(534):36-9.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2032698/?tool=pubmed
http://www.ncbi.nlm.nih.gov/pubmed/17244422?tool=bestpractice.com
[4]Bland JD, Rudolfer SM. Clinical surveillance of carpal tunnel syndrome in two areas of the United Kingdom, 1991-2001. J Neurol Neurosurg Psychiatry. 2003 Dec;74(12):1674-9.
https://jnnp.bmj.com/content/74/12/1674.long
http://www.ncbi.nlm.nih.gov/pubmed/14638888?tool=bestpractice.com
[5]Burton CL, Chen Y, Chesterton LS, et al. Trends in the prevalence, incidence and surgical management of carpal tunnel syndrome between 1993 and 2013: an observational analysis of UK primary care records. BMJ Open. 2018 Jun 19;8(6):e020166.
https://bmjopen.bmj.com/content/8/6/e020166.long
http://www.ncbi.nlm.nih.gov/pubmed/29921681?tool=bestpractice.com
In the US, the workplace incidence of CTS is estimated at 2.3 cases per 100 person-years, with a prevalence of 7.8%.[6]Dale AM, Harris-Adamson C, Rempel D, et al. Prevalence and incidence of carpal tunnel syndrome in US working populations: pooled analysis of six prospective studies. Scand J Work Environ Health. 2013 Sep 1;39(5):495-505.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042862
http://www.ncbi.nlm.nih.gov/pubmed/23423472?tool=bestpractice.com
One UK study reported an annual incidence ranging from 62 to 120 cases per 100,000 person-years in females, and 35 to 60 cases per 100,000 person-years in males, depending on locality.[4]Bland JD, Rudolfer SM. Clinical surveillance of carpal tunnel syndrome in two areas of the United Kingdom, 1991-2001. J Neurol Neurosurg Psychiatry. 2003 Dec;74(12):1674-9.
https://jnnp.bmj.com/content/74/12/1674.long
http://www.ncbi.nlm.nih.gov/pubmed/14638888?tool=bestpractice.com
In the Netherlands, the crude incidence rate of CTS has been reported as 1.8 cases per 1000 person-years.[2]Bongers FJ, Schellevis FG, van den Bosch WJ, et al. Carpal tunnel syndrome in general practice (1987 and 2001): incidence and the role of occupational and non-occupational factors. Br J Gen Pract. 2007 Jan;57(534):36-9.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2032698/?tool=pubmed
http://www.ncbi.nlm.nih.gov/pubmed/17244422?tool=bestpractice.com
Rates of CTS appear to be rising, although this is likely due to better recognition of the condition.[3]Padua L, Coraci D, Erra C, et al. Carpal tunnel syndrome: clinical features, diagnosis, and management. Lancet Neurol. 2016 Nov;15(12):1273-84.
http://www.ncbi.nlm.nih.gov/pubmed/27751557?tool=bestpractice.com
[5]Burton CL, Chen Y, Chesterton LS, et al. Trends in the prevalence, incidence and surgical management of carpal tunnel syndrome between 1993 and 2013: an observational analysis of UK primary care records. BMJ Open. 2018 Jun 19;8(6):e020166.
https://bmjopen.bmj.com/content/8/6/e020166.long
http://www.ncbi.nlm.nih.gov/pubmed/29921681?tool=bestpractice.com
Epidemiologic data also vary widely as a result of variability in diagnostic criteria between studies.[3]Padua L, Coraci D, Erra C, et al. Carpal tunnel syndrome: clinical features, diagnosis, and management. Lancet Neurol. 2016 Nov;15(12):1273-84.
http://www.ncbi.nlm.nih.gov/pubmed/27751557?tool=bestpractice.com