Monitoring
A complete blood count should be checked routinely to monitor levels of red blood cells (RBCs), white blood cells, and platelets. The interval between testing varies based on the patient's symptoms.
Patients who require regular transfusion should be assessed for iron chelation therapy. Iron chelation therapy can improve event-free survival and should be considered for patients with a favorable prognosis with:[12][15][16][99]
High transfusion burden (e.g., 15 or more RBC transfusions)
Serum ferritin levels exceeding 1000 micrograms/L on repeat measurements.
Candidates for allogeneic stem cell transplantation should receive early chelation therapy.[16]
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