Emerging treatments
Risk stratification using mechanistic biomarkers
In two prospective cohort studies, a combined model of microRNA-122 (miR-122), keratin-18 (K18), and high mobility group box-1 (HMGB1) predicted acute liver injury better than alanine aminotransferase alone in patients who required acetylcysteine treatment for acetaminophen overdose (early-presenting acute overdose or late-presenting acute and staggered overdose).[107] At this time, these biomarkers are not widely available for clinical use.
Use of this content is subject to our disclaimer