Epidemiology

​XP affects people of all races and has been reported on all continents. However, certain regions have a higher incidence than others. The incidence of XP is estimated to be 1 per million live births in the US, 2.3 per million live births in western Europe, 17.5 per million live births in the Middle East, and 45 per million live births in Japan.[5][6][7]​​ Studies have shown that the incidence of XP is increased in countries where consanguinity is common, such as Tunisia, Morocco, Libya and Pakistan.[6][8][9][10][11]​​

Subtype XPC is the most common subtype in the US, Europe, and Africa.[12]

Subtype XPA is the most common subtype in China and Japan, with more than 50% of patients with XP in Japan having the XPA subtype.[2][12][13]​​​

Since XP is an autosomal recessive inherited disorder, males and females are equally affected.

Patients usually present at a young age (<2 years old). The average age at onset of first skin cancer in these patients is <10 years old.[14]​ When adults present with XP, they tend to be aged between 20 and 40 years with numerous premalignant or malignant skin cancers.[2]

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