Children
OME related to acute otitis media (AOM) has a high rate of spontaneous resolution, with 90% resolving by 3 months.[70]Teele DW, Klein JO, Rosner BA. Epidemiology of otitis media in children. Ann Otol Rhinol Laryngol Suppl. 1980 May-Jun;89(3 pt 2):5-6.
http://www.ncbi.nlm.nih.gov/pubmed/6778349?tool=bestpractice.com
OME that is not preceded by AOM has a resolution rate of 28% to 52% within 3-4 months of diagnosis.[71]Rosenfeld RM, Kay D. Natural history of untreated otitis media. Laryngoscope. 2003 Oct;113(10):1645-57.
https://onlinelibrary.wiley.com/doi/full/10.1097/00005537-200310000-00004
http://www.ncbi.nlm.nih.gov/pubmed/14520089?tool=bestpractice.com
[72]Williamson IG, Dunleavey J, Bain J, et al. The natural history of otitis media with effusion-a three-year study of the incidence and prevalence of abnormal tympanograms in four South West Hampshire infant and first schools. J Laryngol Otol. 1994 Nov;108(11):930-4.
http://www.ncbi.nlm.nih.gov/pubmed/7829943?tool=bestpractice.com
Furthermore, 30% to 40% of children in whom OME spontaneously clears will have repeated episodes of OME.[73]Stool SE, Berg AO, Berman S, et al. Otitis media with effusion in young children: clinical practice guideline no. 12. Rockville, MD: Agency for Healthcare Research and Quality; 1994. AHCPR publication 94-0622.[74]Tos M. Epidemiology and natural history of secretory otitis. Am J Otol. 1984 Oct;5(6):459-62.[72]Williamson IG, Dunleavey J, Bain J, et al. The natural history of otitis media with effusion-a three-year study of the incidence and prevalence of abnormal tympanograms in four South West Hampshire infant and first schools. J Laryngol Otol. 1994 Nov;108(11):930-4.
http://www.ncbi.nlm.nih.gov/pubmed/7829943?tool=bestpractice.com
[71]Rosenfeld RM, Kay D. Natural history of untreated otitis media. Laryngoscope. 2003 Oct;113(10):1645-57.
https://onlinelibrary.wiley.com/doi/full/10.1097/00005537-200310000-00004
http://www.ncbi.nlm.nih.gov/pubmed/14520089?tool=bestpractice.com
Risk factors for persistent OME include OME onset during the summer or fall seasons, prior tympanostomy tube placement, no previous adenoidectomy, and hearing loss over 30 dB HL in the better-hearing ear.[106]van Balen FA, de Melker RA. Persistent otitis media with effusion: can it be predicted? A family practice follow-up study in children aged 6 months to 6 years. J Fam Pract. 2000 Jul;49(7):605-11.
http://www.ncbi.nlm.nih.gov/pubmed/10923569?tool=bestpractice.com
[107]Yellon RF, Doyle WJ, Whiteside TL, et al. Cytokines, immunoglobulins, and bacterial pathogens in middle ear effusions. Arch Otolaryngol Head Neck Surg. 1995 Aug;121(8):865-9.
http://www.ncbi.nlm.nih.gov/pubmed/7619411?tool=bestpractice.com
Tympanostomy tube placement with or without adenoidectomy is the gold standard for treatment of chronic OME in children who have hearing loss, speech delay, or are at risk for speech and other developmental sequelae.[53]Rosenfeld RM, Tunkel DE, Schwartz SR, et al. Clinical practice guideline: tympanostomy tubes in children (update). Otolaryngol Head Neck Surg. 2022 Feb;166(1_suppl):S1-55.
https://aao-hnsfjournals.onlinelibrary.wiley.com/doi/10.1177/01945998211065662
http://www.ncbi.nlm.nih.gov/pubmed/35138954?tool=bestpractice.com
Around 14% of children with either OME or AOM require a second set of tubes within 5 years of initial tube placement due to recurrence of OME or AOM.[108]Padia R, Hall D, Sjogren P, et al. Sequelae of tympanostomy tubes in a multihospital health system. Otolaryngol Head Neck Surg. 2018 May;158(5):930-3.
http://www.ncbi.nlm.nih.gov/pubmed/29336221?tool=bestpractice.com
Risk factors for requiring a second set of tympanostomy tubes are younger aged children (<18 months), those with a family history of tympanostomy tube placement for recurrent AOM, or those who had middle ear effusions intraoperatively at the time of the first set of tubes.[109]Huyett P, Sturm JJ, Shaffer AD, et al. Second tympanostomy tube placement in children with recurrent acute otitis media. Laryngoscope. 2018 Jun;128(6):1476-9.
http://www.ncbi.nlm.nih.gov/pubmed/28990661?tool=bestpractice.com
Adults
In adults who do not have an underlying illness as the cause of OME, the rate of spontaneous resolution within one month is around 30%.[75]Mills R, Vaughan-Jones R. A prospective study of otitis media with effusion in adults and children. Clin Otolaryngol Allied Sci. 1992 Jun;17(3):271-4.
http://www.ncbi.nlm.nih.gov/pubmed/1505097?tool=bestpractice.com
Patients with a history of a preceding upper respiratory tract infection are more likely to experience spontaneous resolution of OME.[75]Mills R, Vaughan-Jones R. A prospective study of otitis media with effusion in adults and children. Clin Otolaryngol Allied Sci. 1992 Jun;17(3):271-4.
http://www.ncbi.nlm.nih.gov/pubmed/1505097?tool=bestpractice.com
In practice, tympanostomy tube placement is considered for adult patients with chronic OME. In adults who undergo tympanostomy tube placement for chronic OME, the recurrence rate after tympanostomy tube extrusion is as high as 61%.[110]Yung MW, Arasaratnam R. Adult-onset otitis media with effusion: results following ventilation tube insertion. J Laryngol Otol. 2001 Nov;115(11):874-8.
http://www.ncbi.nlm.nih.gov/pubmed/11779300?tool=bestpractice.com