Emerging treatments
Brivudin
Brivudin is a thymidine nucleoside analog with high in-vitro activity against varicella-zoster virus. It is available for oral administration in some countries in Europe.[77]
Clinacanthus nutans
Clinacanthus nutans is a plant, belonging to the family Acantaceae, that has been used as traditional treatment for bites and infections in Thailand, including skin rashes, and snake and insect bites. It has been reported to have analgesic and anti-inflammatory properties, and has been shown to improve the healing rate of HZ lesions.[110] However, more studies are needed to confirm its efficacy.
Valomaciclovir
Once-daily oral valomaciclovir, a conventional DNA polymerase inhibitor, has been shown to be non-inferior to 3-times daily valacyclovir therapy in immunocompetent patients with HZ infection. More research is needed to further evaluate the efficacy and safety of valomaciclovir.[111]
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