Syndrome of inappropriate antidiuretic hormone

Persistent SIADH

If the underlying cause is found and treated successfully, SIADH typically resolves. If the underlying condition persists, SIADH is difficult to manage, secondary to difficulty complying with necessary fluid restriction or medications. Oral vasopressin antagonists such as tolvaptan offer a hope for more successful long-term management of SIADH, and it has been used in selected patients with careful monitoring.[31]Bondanelli M, Aliberti L, Gagliardi I, et al. Long-term low-dose tolvaptan efficacy and safety in SIADH. Endocrine. 2023 Nov;82(2):390-8. https://pmc.ncbi.nlm.nih.gov/articles/PMC10543144 http://www.ncbi.nlm.nih.gov/pubmed/37507553?tool=bestpractice.com ​