Syndrome of inappropriate antidiuretic hormone

It may be necessary to continue free fluid restriction (1-1.5 L/day) after hypertonic saline therapy and to monitor serum sodium daily until it stabilizes.

Patients with a history of malignancy (especially of pulmonary origin) or of taking offending medications require regular monitoring for the development of SIADH. A chemistry panel every 6 months after diagnosis of a malignancy and 1 to 2 weeks after starting an SIADH-associated medication, with a repeat test after 1-2 months, is usually sufficient.