Differentials
Stable angina
SIGNS / SYMPTOMS
Pain occurs only in context of exertion or emotional stress, not worsening over time, and relieved by nitrates or rest.
INVESTIGATIONS
ECG may be normal in the absence of pain but may show ST depression during episodes of angina or on stress testing.
Prinzmetal (variant or vasospastic) angina
SIGNS / SYMPTOMS
Typically occurs without provocation and usually resolves spontaneously or with rapid-acting nitrate.[2]
May be precipitated by emotional stress, hyperventilation, exercise, or a cold environment.[2][102]
Most episodes occur early in the morning.[2]
May be younger and/or smoker.[2]
Calcium-channel blockers suppress symptoms (beta-blockers do not suppress symptoms).[102]
INVESTIGATIONS
ST elevation during acute episode.[2]
Coronary angiography (invasive or noninvasive) excludes severe obstructive coronary artery disease but may show spasm.[2] (Fixed lesions and spasm may coexist.)
Nonpharmacologic provocative tests (e.g., cold pressor or hyperventilation) or pharmacologic (e.g., acetylcholine) under supervision and in absence of contraindications to provocative testing (left main disease, advanced 3-vessel disease, presence of high-grade obstructive lesions, significant left-ventricular systolic dysfunction, advanced heart failure) may be diagnostic when invasive assessment is not helpful.[2]
Non-ST-elevation myocardial infarction
SIGNS / SYMPTOMS
Clinical presentation may be indistinguishable.
INVESTIGATIONS
ECG may be normal or show ST depression or T wave inversion. Cardiac biomarkers (troponin I and T) are elevated.
ST-elevation myocardial infarction
SIGNS / SYMPTOMS
Clinical presentation may be indistinguishable.
INVESTIGATIONS
ECG shows persistent ST elevation in 2 or more leads. Cardiac biomarkers (troponin I and T) are elevated.
Congestive heart failure
SIGNS / SYMPTOMS
Breathlessness, orthopnea, tachycardia, and peripheral edema are usually predominant. Chest pain may occur if coronary perfusion is poor.
INVESTIGATIONS
Echocardiogram may show reduced left ventricular ejection fraction or signs of diastolic dysfunction with normal left ventricular ejection fraction.
CXR may show congestion, cardiomegaly, or pleural effusion.
B-type natriuretic peptide: elevated.
Chest wall pain
SIGNS / SYMPTOMS
Onset often insidious, and may be history of repetitive movement or minor trauma. Pain may be reproduced on palpation or movement. Not improved with rest or nitrates but may be relieved by local injection of lidocaine.
INVESTIGATIONS
CXR or bone scan may show skeletal pathology such as rib fracture, osteoarthritis, or metastatic tumor. Diagnosis of soft tissue lesions is clinical.
Pericarditis
SIGNS / SYMPTOMS
Recent myocardial infarction, renal failure, chest irradiation, or associated connective tissue disease.
Pain relieved by sitting up and leaning forward and is worse when lying supine. If pleuropericarditis, the pain may be worse or present only on inspiration.
Pericardial rub may be heard.
INVESTIGATIONS
ECG: concave ST elevation in all leads except aVR; PR segment depression.
Echo: may show minimal pericardial effusion, but is frequently normal.
Myocarditis
SIGNS / SYMPTOMS
May be preceded by viral infection.
Symptoms of myocarditis include chest pain (which may be pleuritic as a result of concomitant pericarditis), palpitations, fatigue, or signs of heart failure (e.g., peripheral edema, increasing dyspnea, and weight gain).
INVESTIGATIONS
ECG may show evidence of pericarditis or myopericarditis (ST elevation or nonspecific ST-T changes). Other findings include arrhythmias or conduction disturbances.
Echocardiogram is helpful in excluding other causes of heart failure (e.g., valvular heart disease).
Troponin levels are elevated in up to one third of cases.
Serum viral antibody titers may suggest recent viral infection, but testing is rarely indicated in the diagnosis of viral myocarditis or any dilated cardiomyopathy, owing to its low specificity and the delay of rising viral titers, which would have no impact on therapeutic decisions.
Antimyosin scanning helps in diagnosis and when compared with endomyocardial biopsy shows a sensitivity of 83% and a specificity of 53%.
MRI shows an area of delayed hyper-enhancement that does not match a coronary artery territory.
Endomyocardial biopsy is necessary to establish a confirmed diagnosis of myocarditis. Histologic criteria for myocarditis are well established.[103] However, routine biopsy for establishing diagnosis of myocarditis is rarely helpful clinically, because histologic diagnosis seldom has an impact on therapeutic strategies, unless giant cell myocarditis is suspected.
Aortic dissection
SIGNS / SYMPTOMS
History of hypertension, or Marfan or Ehlers-Danlos syndrome. Occasionally precipitated by pregnancy.
Severe tearing chest pain radiating between shoulder blades.
Unequal pulses, interarm differential blood pressure, diastolic murmur of aortic regurgitation.
INVESTIGATIONS
CXR: may show wide mediastinum.
CT chest or transesophageal echo: visualization of luminal flap will confirm the dissection. ECG may show evidence of inferior ST-elevation myocardial infarction if the right coronary cusp is involved in the dissection, causing blockage of the right coronary artery.
Pulmonary embolism
SIGNS / SYMPTOMS
Recent surgery, immobilization, prolonged air travel, or cancer.
Acute shortness of breath, pleuritic chest pain, or syncope.
Hypoxia, cyanosis, elevated jugular venous pressure with hypotension and clear lung fields.
INVESTIGATIONS
ECG: sinus tachycardia, right bundle branch block, S1Q3T3 pattern.
CXR: oligemic and hyperlucent lung fields, wedge-shaped infarct if pulmonary infarction.
Ventilation-perfusion scan: pulmonary embolism is likely when an area of ventilation is not perfused.
CT angiogram: reveals pulmonary embolism/thrombus.
Pleuritis
SIGNS / SYMPTOMS
Recent viral infection or prodrome of infection.
Chest pain worse with inspiration.
Audible pleuritic rub.
INVESTIGATIONS
CXR: may show resolving pneumonia.
Pneumothorax
SIGNS / SYMPTOMS
Underlying lung disease, trauma, or recent procedures (e.g., insertion of central venous line).
Acute chest pain with shortness of breath.
If large, will lead to tracheal deviation, hyper-resonance, and decreased air entry.
INVESTIGATIONS
CXR: collapsed lung.
Perforated abdominal viscus
SIGNS / SYMPTOMS
History of previous peptic ulcer disease, diverticulitis, or recent bowel biopsy.
Typically presents with abdominal pain. Chest pain is referred but may be mistaken for cardiac origin.
Abdominal examination shows localized tenderness and, in cases of peritonitis, generalized tenderness.
INVESTIGATIONS
Erect CXR and abdominal series: gas under the diaphragm.
CT abdomen: confirm the presence of free gas within the abdomen and peritoneal cavity.
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