Criteria
Diagnostic criteria for Bartonella henselae infection (adapted from Margileth)[31][52]
Presence of any 3 of the following 4 criteria confirms diagnosis of B henselae infection:
Cat or flea contact regardless of presence of a scratch mark or a lesion at the inoculation site
Negative tuberculin skin test or interferon-gamma release assays, or negative serologies for other causes of adenopathy; sterile pus aspirated from node; positive polymerase chain reaction (PCR) assay for B henselae; and/or liver/spleen lesions seen on computed tomography scan
Positive enzyme immunoassay or immunofluorescent antibody assay with a single titer of ≥1:64 or a fourfold rise in titer between acute and convalescent phases
Biopsy showing granulomatous inflammation consistent with cat-scratch disease, or a positive Warthin-Starry silver stain.
Proposed diagnostic criteria for Bartonella endocarditis[53]
One study recommends the presence of one of the following criteria be considered major Duke criteria for Bartonella endocarditis:
Positive PCR result from a cardiac valve or blood specimen
IgG titer ≥800 (immunofluorescence assay)
Positive Western blot assay.
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