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Last reviewed: 21 Mar 2025
Last updated: 24 Jan 2025

Summary

Definition

History and exam

Key diagnostic factors

  • consumption of raw or undercooked meat
  • sick contacts
  • myalgia and myositis
  • fever
  • periorbital/facial edema
  • conjunctivitis and subconjunctival hemorrhages

Other diagnostic factors

  • subungual and retinal splinter hemorrhages
  • other ocular features
  • gastrointestinal signs and symptoms
  • hepatomegaly
  • oliguria
  • maculopapular rash
  • other cutaneous features
  • dysphagia
  • dysphonia
  • dyspnea
  • headache
  • paralysis-like state
  • other neurologic features

Risk factors

  • consumption of raw or undercooked pork
  • consumption of raw or undercooked horse or other domestic animal meat
  • consumption of raw or undercooked wild game meat
  • consumption of raw or undercooked reptile meat

Diagnostic tests

1st tests to order

  • CBC with differential
  • creatine kinase and other muscle enzymes
  • serum potassium
  • serum albumin
  • serum IgE

Tests to consider

  • antibody serology
  • muscle biopsy
  • electromyography
  • urinalysis
  • serum creatinine and creatinine clearance
  • serum aminotransferases
  • MRI or CT brain
  • EEG
  • cerebrospinal fluid analysis
  • ECG
  • serum troponin
  • Two-dimensional echocardiography

Treatment algorithm

Contributors

Authors

Miguel G. Madariaga, MD, MSc, FACP
Miguel G. Madariaga

Infectious Diseases Consultant

Naples Community Hospital

Naples

FL

Disclosures

MGM declares that he has no competing interests.

Peer reviewers

Fabrizio Bruschi, MD

Professor of Parasitology

Department of Experimental Pathology BMIE

Faculty of Medicine and Surgery

University of Pisa

Pisa

Italy

Disclosures

FB is an author of a number of references cited in this topic.

Jean Dupouy-Camet, MD, PhD

Chef du Service de Parasitologie-Mycologie

Hôpital Cochin

Paris

France

Disclosures

JDC is an author of a number of references cited in this topic. JDC declares that he has no competing interests.

Christopher D. Huston, MD

Associate Professor

Division of Infectious Diseases

Department of Medicine

University of Vermont College of Medicine

Burlington

VT

Disclosures

CDH declares that he has no competing interests.

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