Prognosis
This is among the most common and disabling mental disorders. It can be chronic, and access to treatment is often delayed or avoided. About 70% to 80% of cases have a lifetime history of concurrent anxiety, depression, and/or substance-use disorders. Effective management requires early detection, education, and delivery of evidence-based pharmacotherapy and/or cognitive behavioral therapy (CBT). Long-term treatment is often recommended due to relapse potential. Relapse may occur in 30% to 50% of patients following medication discontinuation.[108][166][167] Relapse rates may be attenuated in those who have received elements of CBT.[137] In addition, it appears that the probability of relapse may be reduced following periodic "booster" CBT sessions.
Failure to respond to initial treatment should prompt reconsideration of diagnosis and evaluation of other medical conditions that may be contributing to the clinical presentation. Treatment-resistant patients should be referred to a mental health professional with expertise in the management of anxiety disorders. Ambivalence in accepting a psychiatric referral should be discussed with the patient, and they should be provided with corrective information and motivational enhancements where indicated.
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