The prognosis of interatrial communications without pulmonary vascular obstructive disease is excellent. The surgical mortality of an uncomplicated closure of an interatrial communication is less than 0.5%.[36]Fuller SM, He X, Jacobs JP, et al. Estimating mortality risk for adult congenital heart surgery: an analysis of The Society of Thoracic Surgeons Congenital Heart Surgery Database. Ann Thorac Surg. 2015 Nov;100(5):1728-35;discussion 1735-6.
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http://www.ncbi.nlm.nih.gov/pubmed/26411754?tool=bestpractice.com
Transcatheter closure of interatrial communications has shown equivalent results compared with surgery, but a higher long-term reintervention rate.[37]DiBardino DJ, McElhinney DB, Kaza AK, et al. Analysis of the US Food and Drug Administration Manufacturer and User Facility Device Experience database for adverse events involving Amplatzer septal occluder devices and comparison with the Society of Thoracic Surgery congenital cardiac surgery database. J Thorac Cardiovasc Surg. 2009 Jun;137(6):1334-41.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230527
http://www.ncbi.nlm.nih.gov/pubmed/19464444?tool=bestpractice.com
Older age at the time of repair of an interatrial communication is associated with a higher rate of adverse events.[38]Abrahamyan L, Dharma C, Alnasser S, et al. Long-term outcomes after atrial septal defect transcatheter closure by age and against population controls. JACC Cardiovasc Interv. 2021 Mar 8;14(5):566-75.
https://www.sciencedirect.com/science/article/pii/S1936879820325073?via%3Dihub
http://www.ncbi.nlm.nih.gov/pubmed/33663785?tool=bestpractice.com
Life expectancy in patients with uncomplicated defects is equivalent to that of the normal population.
The incidence of device erosion is <1%, and likely <1 in 1000.[39]McElhinney DB, Quartermain MD, Kenny D, et al. Relative risk factors for cardiac erosion following transcatheter closure of atrial septal defects: a case-control study. Circulation. 2016 May 3;133(18):1738-46.
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http://www.ncbi.nlm.nih.gov/pubmed/27002094?tool=bestpractice.com
Shunt reversal with inoperable Eisenmenger physiology is associated with a poor prognosis, as is persistent or recurrent pulmonary hypertension after surgical repair.[10]Jone PN, Ivy DD, Hauck A, et al. Pulmonary hypertension in congenital heart disease: a scientific statement from the American Heart Association. Circ Heart Fail. 2023 Jul;16(7):e00080.
https://www.ahajournals.org/doi/10.1161/HHF.0000000000000080
http://www.ncbi.nlm.nih.gov/pubmed/37357777?tool=bestpractice.com