The National Institutes of Health stroke scale
A scoring system to measure severity of ischemic injury.
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NIH Stroke Score
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Performance on each of the following components of exam (carried out in the order listed) is scored:
Level of Consciousness (LOC): LOC Scale; LOC questions; LOC commands
Best gaze
Visual: visual fields are tested
Facial palsy
Motor arm: arms are individually assessed for drift - each is scored separately
Motor leg: legs are individually assessed for drift - each is scored separately
Limb ataxia: presence in one or more limbs
Sensory: evidence of sensory loss to pinprick
Best language: assessment of aphasia using description of a picture
Dysarthria: patient is asked to repeat words on a defined list
Extinction and inattention: tests for inattention or extinction in 2 of the sensory modalities, vision and light touch.
Scores are totaled and a severity rating is given.
ABCD2 score[75]Giles MF, Rothwell PM. Risk of stroke early after transient ischemic attack: a systematic review and meta-analysis. Lancet Neurol. 2007 Dec;6(12):1063-72.
http://www.ncbi.nlm.nih.gov/pubmed/17993293?tool=bestpractice.com
[76]Johnston SC, Rothwell PM, Nguyen-Huynh MN, et al. Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack. Lancet. 2007 Jan 27;369(9558):283-92.
http://www.ncbi.nlm.nih.gov/pubmed/17258668?tool=bestpractice.com
Can be used to help predict the risk of stroke following TIA.
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ABCD2 Score to Predict Stroke Risk after TIA
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Risk factor points (maximum score 7 points)
Age ≥60 years: 1 point
BP ≥140 mmHg (systolic) or ≥90 mmHg (diastolic): 1 point
Clinical deficit of unilateral weakness: 2 points; or clinical deficit of speech impairment: 1 point
Duration ≥60 minutes: 2 points; or duration 10 to 59 minutes: 1 point
Diabetes: 1 point.
Risk categories
Low (0-3 points): 2-day stroke risk of 1%
Intermediate (4-5 points): 2-day stroke risk of 4.1%
High (6-7 points): 2-day stroke risk of 8.1%.
Refinements to the ABCD2 score, including the ABCD3 and ABCD3-I, have been validated and continue to be refined.[57]Kiyohara T, Kamouchi M, Kumai Y, et al. ABCD3 and ABCD3-I scores are superior to ABCD2 score in the prediction of short- and long-term risks of stroke after transient ischemic attack. Stroke. 2014 Feb;45(2):418-25.
https://www.ahajournals.org/doi/full/10.1161/strokeaha.113.003077
http://www.ncbi.nlm.nih.gov/pubmed/24335223?tool=bestpractice.com
[77]Dai Q, Sun W, Xiong Y, et al. From clinical to tissue-based dual TIA: validation and refinement of ABCD3-I score. Neurology. 2015 Apr 7;84(14):1426-32.
http://www.ncbi.nlm.nih.gov/pubmed/25746561?tool=bestpractice.com
ABCD3 adds the presence of >2 TIAs in a week to the predictive model and ABCD3-I uses additional imaging data to improve prediction. There is some evidence to suggest that the ABCD3-I score is the most effective.[57]Kiyohara T, Kamouchi M, Kumai Y, et al. ABCD3 and ABCD3-I scores are superior to ABCD2 score in the prediction of short- and long-term risks of stroke after transient ischemic attack. Stroke. 2014 Feb;45(2):418-25.
https://www.ahajournals.org/doi/full/10.1161/strokeaha.113.003077
http://www.ncbi.nlm.nih.gov/pubmed/24335223?tool=bestpractice.com
[58]Kelly PJ, Albers GW, Chatzikonstantinou A, et al. Validation and comparison of imaging-based scores for prediction of early stroke risk after transient ischaemic attack: a pooled analysis of individual-patient data from cohort studies. Lancet Neurol. 2016 Nov;15(12):1238-47.
http://www.ncbi.nlm.nih.gov/pubmed/27751555?tool=bestpractice.com
Evidence shows that risk prediction scores used in isolation are poor at discriminating low and high risk of stroke after TIA.[58]Kelly PJ, Albers GW, Chatzikonstantinou A, et al. Validation and comparison of imaging-based scores for prediction of early stroke risk after transient ischaemic attack: a pooled analysis of individual-patient data from cohort studies. Lancet Neurol. 2016 Nov;15(12):1238-47.
http://www.ncbi.nlm.nih.gov/pubmed/27751555?tool=bestpractice.com
[59]Merwick A, Albers GW, Amarenco P, et al. Addition of brain and carotid imaging to the ABCD² score to identify patients at early risk of stroke after transient ischaemic attack: a multicentre observational study. Lancet Neurol. 2010 Nov;9(11):1060-9.
http://www.ncbi.nlm.nih.gov/pubmed/20934388?tool=bestpractice.com
This has led some national guidelines outside the US, e.g., the National Institute for Health and Care Excellence (NICE) in the UK, to recommend that all people with suspected TIA are considered as potentially high risk for stroke, with specialist assessment and investigation within 24 hours of symptom onset.[43]National Institute for Health and Care Excellence. Stroke and transient ischaemic attack in over 16s: diagnosis and initial management. Apr 2022 [internet publication].
https://www.nice.org.uk/guidance/ng128