Given the relative predictability of seasonal changes and risk for seasonal affective disorder (SAD) symptom onset, the risks and benefits of prophylactic treatments across time should be discussed with the patient.[54]Westrin A, Lam RW. Long-term and preventative treatment for seasonal affective disorder. CNS Drugs. 2007;21(11):901-9.
http://www.ncbi.nlm.nih.gov/pubmed/17927295?tool=bestpractice.com
Prophylactic measures can be taken in the months before the seasonal mood pattern, and include:[15]Magnusson A, Partonen T. The diagnosis, symptomatology, and epidemiology of seasonal affective disorder. CNS Spectr. 2005 Aug;10(8):625-34.
http://www.ncbi.nlm.nih.gov/pubmed/16041294?tool=bestpractice.com
[54]Westrin A, Lam RW. Long-term and preventative treatment for seasonal affective disorder. CNS Drugs. 2007;21(11):901-9.
http://www.ncbi.nlm.nih.gov/pubmed/17927295?tool=bestpractice.com
Bright-light therapy
Bupropion (extended-release)
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How does bupropion compare with placebo for preventing seasonal affective disorder (SAD)?/cca.html?targetUrl=https://www.cochranelibrary.com/cca/doi/10.1002/cca.2226/fullShow me the answer
Ongoing antidepressant therapy
Moving to a more southerly latitude.
Outcome trials are very limited, but do show some support for using bright light therapy to prevent relapsing symptoms.[86]Nussbaumer-Streit B, Forneris CA, Morgan LC, et al. Light therapy for preventing seasonal affective disorder. Cochrane Database Syst Rev. 2019 Mar 18;3:CD011269.
https://www.doi.org/10.1002/14651858.CD011269.pub3
http://www.ncbi.nlm.nih.gov/pubmed/30883670?tool=bestpractice.com
Bupropion (extended-release) is the only approved drug for prevention of SAD in some countries.[6]Galima SV, Vogel SR, Kowalski AW. Seasonal affective disorder: common questions and answers. Am Fam Physician. 2020 Dec 1;102(11):668-72.
https://www.aafp.org/pubs/afp/issues/2020/1201/p668.html
http://www.ncbi.nlm.nih.gov/pubmed/33252911?tool=bestpractice.com
[85]Modell JG, Rosenthal NE, Harriett AE, et al. Seasonal affective disorder and its prevention by anticipatory treatment with bupropion XL. Biol Psychiatry. 2005 Oct 15;58(8):658-67.
http://www.ncbi.nlm.nih.gov/pubmed/16271314?tool=bestpractice.com
Treatment begins in early autumn and should be continued through winter.[85]Modell JG, Rosenthal NE, Harriett AE, et al. Seasonal affective disorder and its prevention by anticipatory treatment with bupropion XL. Biol Psychiatry. 2005 Oct 15;58(8):658-67.
http://www.ncbi.nlm.nih.gov/pubmed/16271314?tool=bestpractice.com
Bupropion is unstudied as an acute treatment for mid-episode seasonal depression. Bupropion is not recommended for patients with a history of bipolar disorder. Initiation of antidepressant pharmacotherapy after successful treatment of seasonal depression may also be helpful in preventing relapse.[76]Cleare A, Pariante CM, Young AH, et al. Evidence-based guidelines for treating depressive disorders with antidepressants: a revision of the 2008 British Association for Psychopharmacology guidelines. J Psychopharmacol. 2015 May;29(5):459-525.
https://www.bap.org.uk/pdfs/BAP_Guidelines-Antidepressants.pdf
http://www.ncbi.nlm.nih.gov/pubmed/25969470?tool=bestpractice.com
Cognitive behavioural therapy may also help prevent the recurrence of seasonal depression.[101]Rohan KJ, Roecklein KA, Lacy TJ, et al. Winter depression recurrence one
year after cognitive-behavioral therapy, light therapy, or combination treatment.
Behav Ther. 2009 Sep;40(3):225-38.
http://www.ncbi.nlm.nih.gov/pubmed/19647524?tool=bestpractice.com