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Last reviewed: 9 Mar 2025
Last updated: 25 Mar 2025

Summary

Definition

History and exam

Key diagnostic factors

  • presence of risk factors
  • ≥2-year period of seasonally related changes in mood
  • autumn or winter depression
  • spring or summer symptom remission
  • atypical depressive symptoms
  • vegetative depressive symptoms
  • spring or summer manic or hypomanic symptoms
  • spring or summer depression
  • manic/hypomanic symptoms

Other diagnostic factors

  • somatic symptoms
  • behavioural withdrawal
  • functional impairments
  • excessive alcohol use
  • tachycardia
  • increased systolic blood pressure
  • restlessness

Risk factors

  • exposure to diminished light during winter and increased light during summer
  • residing at a northern latitude
  • family history of seasonal affective disorder (SAD)
  • female sex
  • age 20 to 30 years
  • psychological factors (e.g., high neuroticism)
  • psychiatric comorbidity (e.g., anxiety, ADHD, premenstrual dysphoric disorders)
  • alcohol use

Diagnostic investigations

Investigations to consider

  • blood metabolic panel
  • serum thyroid-stimulating hormone
  • toxicology screen (urine and blood)

Treatment algorithm

Contributors

Authors

Craig N. Sawchuk, PhD
Craig N. Sawchuk

Associate Professor

Co-Chair, Division of Integrated Behavioral Health

Department of Psychiatry and Psychology

Mayo Clinic

Rochester

MN

Disclosures

CNS declares that he has no competing interests.

Jason P. Veitengruber, MD
Jason P. Veitengruber

Assistant Professor

Department of Psychiatry and Behavioral Sciences

University of Washington School of Medicine

Seattle

WA

Disclosures

JPV declares that he has no competing interests.

William B. Leasure, MD

Clinical Instructor

Department of Psychiatry and Psychology

Mayo Clinic

Rochester

MN

Disclosures

WBL declares that he has no competing interests.

Peer reviewers

Gregory W. Dalack, MD

Professor and Chair

University of Michigan

Department of Psychiatry

Ann Arbor

MI

Disclosures

GWD declares that he has no competing interests.

Dietmar Winkler, MD

Department of Psychiatry and Psychotherapy

Medical University of Vienna

Vienna

Austria

Disclosures

DW is an author of a number of references cited in this topic. DW declares that he has no competing interests.

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