Histoplasmosis

Patients with underlying chronic lung disease or emphysema may develop chronic cavitary histoplasmosis, which presents with productive cough, weight loss, fevers, malaise, and possibly haemoptysis.

Without treatment the disease is progressive and may result in death.

This is an uncommon but documented manifestation of disseminated histoplasmosis.

Sepsis in adults

Following intensive exposure, patients with acute pulmonary histoplasmosis may show diffuse reticulonodular infiltrates on chest x-ray and have respiratory distress, and the condition may progress to respiratory failure. See Acute respiratory failure

Acute respiratory failure

Following intensive exposure, patients with acute pulmonary histoplasmosis may show diffuse reticulonodular infiltrates on chest x-ray and have respiratory distress, and the condition may progress to acute respiratory distress syndrome. See Acute respiratory distress syndrome

Acute respiratory distress syndrome

Treatment is more likely to fail in the context of an impaired host or certain forms of disease (chronic pulmonary disease). It may manifest as a failure to respond to therapy or as disease recurrence.