Criteria
Diagnostic criteria for primary sclerosing cholangitis: summary of a workshop[1]
The major criteria for the diagnosis are:
Cholangiography with multi-focal stricturing of the intra- and/or extrahepatic bile ducts
Biochemical evidence of cholestasis
Exclusion of secondary causes.
Histological staging[44]
Stage 1: bile duct injury and portal inflammation with minimal fibrosis.
Stage 2: expansion of portal tracts, periportal fibrosis, and inflammation.
Stage 3: fibrous septa, bridging fibrosis, more prominent ductopenia.
Stage 4: cirrhosis.
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