Cochrane Clinical Answers

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Cochrane Clinical Answers (CCAs) provide a readable, digestible, clinically focused entry point to rigorous research from Cochrane systematic reviews. They are designed to be actionable and to inform decision making at the point of care and have been added to relevant sections of the main Best Practice text.

  • How does delayed cord clamping (DCC) followed by immediate neonatal care compare with early cord clamping (ECC) for babies born before 37 weeks' gestation?
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  • How does early nasal intermittent positive pressure ventilation (NIPPV) compare with early nasal continuous positive airway pressure (NCPAP) in preterm infants?
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  • In low birthweight infants, is there randomized controlled trial evidence to support the use of kangaroo mother care instead of conventional neonatal care?
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  • What are the benefits and harms of H2 receptor antagonists (H2RA) or proton pump inhibitors (PPI) for treating newborn infants with upper gastrointestinal bleeding?
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  • How does volume-targeted ventilation compare with traditional pressure-limited ventilation for neonates?
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  • How do lower and higher ranges of targeted oxygen saturation compare in preterm infants?
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  • In preterm and/or low birth weight infants, how does plastic wrap or bag compare with routine care for preventing hypothermia?
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  • What are the benefits and harms of responsive versus scheduled feeding in preterm infants?
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  • What are the effects of early trophic feeding versus enteral fasting in very preterm or very low birth weight infants?
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  • How does nutrient-enriched formula compare with standard formula given to preterm infants after hospital discharge?
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  • What are the benefits and harms of inhaled nitric oxide for preterm infants with respiratory failure?
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  • For very preterm or very low birth weight infants, what are the effects of probiotics for preventing necrotizing enterocolitis?
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  • Does enteral lactoferrin supplementation prevent sepsis and necrotizing enterocolitis in preterm infants?
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  • Does oral lactoferrin prevent sepsis and necrotizing enterocolitis in preterm infants?
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  • What are the effects of early developmental intervention programs for preventing motor and cognitive impairments in preterm infants?
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