Investigations

1st investigations to order

urinalysis

Test
Result
Test

Because women with gestational hypertension are at increased risk of pre-eclampsia, a urine dipstick test is recommended on each antenatal visit.

Result

negative or <2+ protein

FBC

Test
Result
Test

Baseline test to screen for pre-eclampsia at diagnosis.

Result

within pregnancy-specific thresholds

LFTs

Test
Result
Test

Baseline test to screen for pre-eclampsia at diagnosis.

Result

within pregnancy-specific thresholds

electrolytes, urea, creatinine

Test
Result
Test

Baseline test to screen for pre-eclampsia at diagnosis.

Result

within pregnancy-specific thresholds

placental growth factor

Test
Result
Test

Where available, measurement of maternal placental growth factor may reduce the time to diagnosis of pre-eclampsia, with consequent reduction in incidence of severe maternal adverse outcomes.[6][29][30]

Result

low

Investigations to consider

uric acid

Test
Result
Test

May be considered to screen for pre-eclampsia, although it is neither sensitive nor specific.

Result

may be elevated in pre-eclampsia

24-hour BP monitoring

Test
Result
Test

Useful if static BPs are equivocal.

Result

elevated

fetal ultrasound

Test
Result
Test

Recommended on diagnosis.

Result

baseline estimation of fetal weight and amniotic fluid index

umbilical artery Doppler velocimetry

Test
Result
Test

Recommended on diagnosis.

Result

baseline estimation of vascular haemodynamics, including end diastolic flow

proteinuria (spot testing, 24-hour urine collection)

Test
Result
Test

This will rarely be required in women who have a negative urinalysis for protein.

Twenty-four hour urine collection is awkward for women and, where available, alternative spot tests such as protein:creatinine ratio and albumin:creatinine ratio are preferred.[1]​​[6]

Result

protein:creatinine ratio <30 mg/mmol; albumin:creatinine ratio <8 mg/mmol; 24-hour urine collection <300 mg in 24 hours

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