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Last reviewed: 16 Mar 2025
Last updated: 06 Dec 2024

Summary

Definition

History and exam

Key diagnostic factors

  • presence of risk factors
  • previously normotensive
  • BP ≥140/90 mmHg

Other diagnostic factors

  • >20 weeks' gestation
  • absence of symptoms that suggest pre-eclampsia

Risk factors

  • nulliparous
  • maternal age >35 years
  • black or Hispanic ethnicity
  • obesity
  • mother small for gestational age
  • type 1 diabetes mellitus
  • migraine

Diagnostic investigations

1st investigations to order

  • urinalysis
  • FBC
  • LFTs
  • electrolytes, urea, creatinine
  • placental growth factor

Investigations to consider

  • uric acid
  • 24-hour BP monitoring
  • fetal ultrasound
  • umbilical artery Doppler velocimetry
  • proteinuria (spot testing, 24-hour urine collection)

Treatment algorithm

Contributors

Authors

Aparna Sundaram, DO, MBA, MPH

Board-certified in Preventive Medicine

Board Certified in Lifestyle Medicine

Preventive Medicine Consultants, PLLC

Glendale

AZ

Disclosures

AS declares that she has no competing interests.

Peer reviewers

Caroline Apovian, MD

Associate Professor of Medicine

Boston University School of Medicine

Boston

MA

Disclosures

CA declares that she has no competing interests.

James Walker, MD, FRCP(Glas), FRCP(Edin), FRCOG

Professor of Obstetrics and Gynaecology

St James's University Hospital

Leeds

UK

Disclosures

JW declares that he has no competing interests.

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