As soon as the patient is diagnosed with coeliac disease, they should be advised to avoid all products containing wheat, rye, barley, and spelt.
National Digestive Diseases Information Clearinghouse: celiac disease
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National Celiac Association
Opens in new window Although not technically a trigger for coeliac disease, many oat products are contaminated with wheat, and a minority of patients with coeliac disease may be oat-intolerant. There is substantial evidence that oats that are not contaminated by wheat or barley are safe for the vast majority of patients with coeliac disease.[148]Holm K, Maki M, Vuolteenaho N, et al. Oats in the treatment of childhood coeliac disease: a 2-year controlled trial and a long-term clinical follow-up study. Aliment Pharmacol Ther. 2006 May 15;23(10):1463-72.
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2006.02908.x/full
http://www.ncbi.nlm.nih.gov/pubmed/16669961?tool=bestpractice.com
[149]Hogberg L, Laurin P, Falth-Magnusson K, et al. Oats to children with newly diagnosed coeliac disease: a randomised double blind study. Gut. 2004 May;53(5):649-54.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1774046
http://www.ncbi.nlm.nih.gov/pubmed/15082581?tool=bestpractice.com
[150]Garsed K, Scott BB. Can oats be taken in a gluten-free diet? A systematic review. Scand J Gastroenterol. 2007 Feb;42(2):171-8.
http://www.ncbi.nlm.nih.gov/pubmed/17327936?tool=bestpractice.com
Some patients may, however, be sensitive.[151]Pinto-Sánchez MI, Causada-Calo N, Bercik P, et al. Safety of adding oats to a gluten-free diet for patients with celiac disease: systematic review and meta-analysis of clinical and observational studies. Gastroenterology. 2017 Aug;153(2):395-409;e3.
https://www.gastrojournal.org/article/S0016-5085(17)35474-4/fulltext?referrer=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F28431885%2F
http://www.ncbi.nlm.nih.gov/pubmed/28431885?tool=bestpractice.com
The American College of Gastroenterology guidelines recommend inclusion of gluten-free oats in diets of patients with coeliac disease.[73]Chaudrey KH. ACG guideline: diagnosis and management of celiac disease. Am J Gastroenterol. 2023;118(1):23.
http://www.ncbi.nlm.nih.gov/pubmed/36602833?tool=bestpractice.com
In North America, some food manufacturers operate under a 'Purity Protocol' which involves harvesting, transporting, storing, processing and manufacturing oats using processes that minimise the presence of gluten.[152]Allred LK, Kupper C, Iverson G, et al. Definition of the “Purity Protocol” for producing gluten-free oats. Cereal Chem. (2017) 94:377–9.
https://onlinelibrary.wiley.com/doi/epdf/10.1094/CCHEM-01-17-0017-VO
Oats are not recommended as part of a gluten-free diet in some countries, and local guidance should be consulted before recommending them.
The gluten-free diet is demanding, especially at the outset, and referral to both a dietitian skilled in coeliac disease and a local support/advocacy group is strongly recommended. Patients should be reassured that adopting the diet is a challenge and mistakes and difficulties adjusting early on are common. Factors improving overall adherence to a gluten-free diet include improving knowledge about the diet, becoming a member of a coeliac association, increased education, and increased self-regulatory efficacy.[195]Abu-Janb N, Jaana M. Facilitators and barriers to adherence to gluten-free diet among adults with celiac disease: a systematic review. J Hum Nutr Diet. 2020 Dec;33(6):786-810.
http://www.ncbi.nlm.nih.gov/pubmed/32348008?tool=bestpractice.com
Counselling with a therapist may be recommended, as people with coeliac disease may be at risk of disordered eating patterns.[196]Peters JE, Basnayake C, Hebbard GS, et al. Prevalence of disordered eating in adults with gastrointestinal disorders: a systematic review. Neurogastroenterol Motil. 2022 Aug;34(8):e14278.
http://www.ncbi.nlm.nih.gov/pubmed/34618988?tool=bestpractice.com
Hidden sources of gluten
Under ideal circumstances, a 'gluten-free diet' should exclude all gluten-containing foods. However, despite adopting strict dietary modifications, at least one third of patients with coeliac disease are exposed to gluten.[197]Wieser H, Segura V, Ruiz-Carnicer Á, et al. Food safety and cross-contamination of gluten-free products: a narrative review. Nutrients. 2021 Jun 29;13(7):2244.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308338
http://www.ncbi.nlm.nih.gov/pubmed/34210037?tool=bestpractice.com
Many natural and certified gluten-free foods are prone to contamination and have gluten levels above the 20 mg/kg threshold set by Codex Alimentarius 118-1979.[198]Food and Agriculture Orgnaisation of the United Nations. Standard for foods for special dietary use for person intolerant to gluten. 2008 [internet publication].
https://www.fao.org/fao-who-codexalimentarius/sh-proxy/en/?lnk=1&url=https%253A%252F%252Fworkspace.fao.org%252Fsites%252Fcodex%252FStandards%252FCXS%2B118-1979%252FCXS_118e_2015.pdf
[199]Gibert A, Kruizinga AG, Neuhold S, et al. Might gluten traces in wheat substitutes pose a risk in patients with celiac disease? A population-based probabilistic approach to risk estimation. Am J Clin Nutr. 2013 Jan;97(1):109-16.
https://www.sciencedirect.com/science/article/pii/S0002916523053790?via%3Dihub
http://www.ncbi.nlm.nih.gov/pubmed/23193005?tool=bestpractice.com
[200]Sharma GM, Pereira M, Williams KM. Gluten detection in foods available in the United States - a market survey. Food Chem. 2015 Feb 15;169:120-6.
http://www.ncbi.nlm.nih.gov/pubmed/25236206?tool=bestpractice.com
[201]Koerner TB, Cleroux C, Poirier C, et al. Gluten contamination of naturally gluten-free flours and starches used by Canadians with celiac disease. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2013;30(12):2017-21.
http://www.ncbi.nlm.nih.gov/pubmed/24124879?tool=bestpractice.com
Improper labelling, social constraints, and ubiquity of gluten proteins in raw or cooked food and medicines can also lead to accidental encounters with gluten. Further, inadvertent exposure to gluten can happen through restaurant meals, consumption of composite foods, and use of oral hygiene and cosmetic products containing hidden gluten.[202]Lerner BA, Phan Vo LT, Yates S, et al. Detection of gluten in gluten-free labeled restaurant food: analysis of crowd-sourced data. Am J Gastroenterol. 2019 May;114(5):792-7.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502671
http://www.ncbi.nlm.nih.gov/pubmed/30920417?tool=bestpractice.com
[203]Falcomer AL, Santos Araújo L, Farage P, et al. Gluten contamination in food services and industry: A systematic review. Crit Rev Food Sci Nutr. 2020;60(3):479-93.
http://www.ncbi.nlm.nih.gov/pubmed/30582343?tool=bestpractice.com
[204]Verma AK, Lionetti E, Gatti S, et al. Contribution of oral hygiene and cosmetics on contamination of gluten-free diet: do celiac customers need to worry about? J Pediatr Gastroenterol Nutr. 2019 Jan;68(1):26-9.
http://www.ncbi.nlm.nih.gov/pubmed/30119098?tool=bestpractice.com
Using separate manufacturing and processing areas for gluten-containing and gluten-free products may be one possible solution to this problem.[205]Demirkesen I, Ozkaya B. Recent strategies for tackling the problems in gluten-free diet and products. Crit Rev Food Sci Nutr. 2022;62(3):571-97.
http://www.ncbi.nlm.nih.gov/pubmed/32981341?tool=bestpractice.com