Epidemiology

PDB is the second most common chronic bone-remodelling disorder after osteoporosis.[3] The majority of cases are sporadic, but between 5% and 40% of patients report a first-degree relative with PDB.[4]

An overall prevalence of 2% has been reported in the UK.[5] Prevalence in Europe is 0.3%.[6] In the US, prevalence is approximately 1% in the general population, rising to 2.32% in people aged 65 to 74 years.[7] The mean age of onset is 55 years, with equal distribution among men and women (although there is a slight male predominance in the 45- to 74-years age group).[7] A decrease in prevalence since the 1990s has been reported in most countries.[8]

PDB may be either monostotic (25%), involving most frequently the femur, or polyostotic (75%), involving most frequently the femur, pelvis, skull, tibia, or vertebrae.[1][2] 

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