Acanthosis nigricans

Any woman treated with isotretinoin must be counselled about pregnancy avoidance.[54]US Food and Drug Administration. iPLEDGE risk evaluation and mitigation strategy (REMS). Nov 2023 [internet publication]. https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/ipledge-risk-evaluation-and-mitigation-strategy-rems [55]Medicines and Healthcare products Regulatory Agency. Oral retinoids: pregnancy prevention-reminder of measures to minimise teratogenic risk. Dec 2014 [internet publication]. https://www.gov.uk/drug-safety-update/oral-retinoids-pregnancy-prevention-reminder-of-measures-to-minimise-teratogenic-risk [56]Retinoids: EMA updated warnings. Drug Ther Bull. 2018 Apr;56(4):40.​​​ ​The use of two methods of birth control for one month prior to treatment, throughout the treatment course, and for one month after treatment is terminated, is mandatory. Pregnancy must also be avoided in women taking acitretin one month prior to treatment, during treatment, and for 3 years after treatment is discontinued, due to the risk of birth defects.