Epidemiology

HL is an uncommon malignancy. In the UK, there were 2166 new cases of HL between 2017 and 2019.[6] It is estimated that 8570 new cases of HL and 910 associated deaths will occur in the US in 2024.[7] The age-adjusted incidence rate in the US is approximately 2.5 per 100,000 people per year (based on data from 2017 to 2021).[7]

Incidence is slightly higher among men than women (2.8 vs. 2.2 per 100,000 people).[7] HL is more common among non-Hispanic white people (3.1 new cases per 100,000 men; 2.6 per 100,000 women) than other racial/ethnic groups.[7]

In the US, median age at diagnosis is 39 years.[7] Peak incidence occurs at ages 20-34 years.[7] Data indicate a bimodal distribution of age at diagnosis, with an initial peak at ages 15-35 years followed by a more modest peak among those >55 years.[6][7]​​[8]

HL incidence rates vary considerably by geographic region, with the highest incidence rates observed in Southern Europe.[8]

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