Avoid exposure to extreme heat, prolonged standing, medications that exacerbate intravascular depletion (e.g., diuretics) or sinus and orthostatic tachycardia (e.g., noradrenaline reuptake inhibitors such as atomoxetine), afterload reduction medications (e.g., ACE inhibitors, angiotensin-II receptor antagonists), excessive alcohol and exercise, and recreational drugs (e.g., cocaine, methamphetamines).[1]Vernino S, Bourne KM, Stiles LE, et al. Postural orthostatic tachycardia syndrome (POTS): state of the science and clinical care from a 2019 National Institutes of Health expert consensus meeting - part 1. Auton Neurosci. 2021 Nov;235:102828.
https://www.doi.org/10.1016/j.autneu.2021.102828
http://www.ncbi.nlm.nih.gov/pubmed/34144933?tool=bestpractice.com
[2]Sheldon RS, Grubb BP 2nd, Olshansky B, et al. 2015 Heart Rhythm Society expert consensus statement on the diagnosis and treatment of postural tachycardia syndrome, inappropriate sinus tachycardia, and vasovagal syncope. Heart Rhythm. 2015 Jun;12(6):e41-63.
https://www.doi.org/10.1016/j.hrthm.2015.03.029
http://www.ncbi.nlm.nih.gov/pubmed/25980576?tool=bestpractice.com
[4]Raj SR, Guzman JC, Harvey P, et al. Canadian Cardiovascular Society position statement on postural orthostatic tachycardia syndrome (POTS) and related disorders of chronic orthostatic intolerance. Can J Cardiol. 2020 Mar;36(3):357-72.
https://www.doi.org/10.1016/j.cjca.2019.12.024
http://www.ncbi.nlm.nih.gov/pubmed/32145864?tool=bestpractice.com
[60]Ricaurte GA, McCann UD. Recognition and management of complications of new recreational drug use. Lancet. 2005 Jun 18-24;365(9477):2137-45.
http://www.ncbi.nlm.nih.gov/pubmed/15964451?tool=bestpractice.com
Drink at least 2 to 3 litres of water per day.[1]Vernino S, Bourne KM, Stiles LE, et al. Postural orthostatic tachycardia syndrome (POTS): state of the science and clinical care from a 2019 National Institutes of Health expert consensus meeting - part 1. Auton Neurosci. 2021 Nov;235:102828.
https://www.doi.org/10.1016/j.autneu.2021.102828
http://www.ncbi.nlm.nih.gov/pubmed/34144933?tool=bestpractice.com
[2]Sheldon RS, Grubb BP 2nd, Olshansky B, et al. 2015 Heart Rhythm Society expert consensus statement on the diagnosis and treatment of postural tachycardia syndrome, inappropriate sinus tachycardia, and vasovagal syncope. Heart Rhythm. 2015 Jun;12(6):e41-63.
https://www.doi.org/10.1016/j.hrthm.2015.03.029
http://www.ncbi.nlm.nih.gov/pubmed/25980576?tool=bestpractice.com
Increase their salt intake up to 10 g per day (1 teaspoon of salt is approximately equivalent to 2.3 g).[1]Vernino S, Bourne KM, Stiles LE, et al. Postural orthostatic tachycardia syndrome (POTS): state of the science and clinical care from a 2019 National Institutes of Health expert consensus meeting - part 1. Auton Neurosci. 2021 Nov;235:102828.
https://www.doi.org/10.1016/j.autneu.2021.102828
http://www.ncbi.nlm.nih.gov/pubmed/34144933?tool=bestpractice.com
[2]Sheldon RS, Grubb BP 2nd, Olshansky B, et al. 2015 Heart Rhythm Society expert consensus statement on the diagnosis and treatment of postural tachycardia syndrome, inappropriate sinus tachycardia, and vasovagal syncope. Heart Rhythm. 2015 Jun;12(6):e41-63.
https://www.doi.org/10.1016/j.hrthm.2015.03.029
http://www.ncbi.nlm.nih.gov/pubmed/25980576?tool=bestpractice.com
[4]Raj SR, Guzman JC, Harvey P, et al. Canadian Cardiovascular Society position statement on postural orthostatic tachycardia syndrome (POTS) and related disorders of chronic orthostatic intolerance. Can J Cardiol. 2020 Mar;36(3):357-72.
https://www.doi.org/10.1016/j.cjca.2019.12.024
http://www.ncbi.nlm.nih.gov/pubmed/32145864?tool=bestpractice.com
[58]Garland EM, Gamboa A, Nwazue VC, et al. Effect of high dietary sodium intake in patients with postural tachycardia syndrome. J Am Coll Cardiol. 2021 May 4;77(17):2174-84.
https://www.doi.org/10.1016/j.jacc.2021.03.005
http://www.ncbi.nlm.nih.gov/pubmed/33926653?tool=bestpractice.com
However, in practice, increased salt intake is an inappropriate treatment for certain patients, such as those with hypertension, or kidney or cardiovascular disease.
Use waist-high compression stockings and/or an abdominal binder to reduce venous pooling in their lower extremities and splanchnic circulation.[1]Vernino S, Bourne KM, Stiles LE, et al. Postural orthostatic tachycardia syndrome (POTS): state of the science and clinical care from a 2019 National Institutes of Health expert consensus meeting - part 1. Auton Neurosci. 2021 Nov;235:102828.
https://www.doi.org/10.1016/j.autneu.2021.102828
http://www.ncbi.nlm.nih.gov/pubmed/34144933?tool=bestpractice.com
[2]Sheldon RS, Grubb BP 2nd, Olshansky B, et al. 2015 Heart Rhythm Society expert consensus statement on the diagnosis and treatment of postural tachycardia syndrome, inappropriate sinus tachycardia, and vasovagal syncope. Heart Rhythm. 2015 Jun;12(6):e41-63.
https://www.doi.org/10.1016/j.hrthm.2015.03.029
http://www.ncbi.nlm.nih.gov/pubmed/25980576?tool=bestpractice.com
[59]Bourne KM, Sheldon RS, Hall J, et al. Compression garment reduces orthostatic tachycardia and symptoms in patients with postural orthostatic tachycardia syndrome. J Am Coll Cardiol. 2021 Jan 26;77(3):285-96.
https://www.doi.org/10.1016/j.jacc.2020.11.040
http://www.ncbi.nlm.nih.gov/pubmed/33478652?tool=bestpractice.com
Undertake graded exercise training, starting with supine progressive aerobic and leg resistance training then progressing to upright exercises.[1]Vernino S, Bourne KM, Stiles LE, et al. Postural orthostatic tachycardia syndrome (POTS): state of the science and clinical care from a 2019 National Institutes of Health expert consensus meeting - part 1. Auton Neurosci. 2021 Nov;235:102828.
https://www.doi.org/10.1016/j.autneu.2021.102828
http://www.ncbi.nlm.nih.gov/pubmed/34144933?tool=bestpractice.com
[2]Sheldon RS, Grubb BP 2nd, Olshansky B, et al. 2015 Heart Rhythm Society expert consensus statement on the diagnosis and treatment of postural tachycardia syndrome, inappropriate sinus tachycardia, and vasovagal syncope. Heart Rhythm. 2015 Jun;12(6):e41-63.
https://www.doi.org/10.1016/j.hrthm.2015.03.029
http://www.ncbi.nlm.nih.gov/pubmed/25980576?tool=bestpractice.com
[4]Raj SR, Guzman JC, Harvey P, et al. Canadian Cardiovascular Society position statement on postural orthostatic tachycardia syndrome (POTS) and related disorders of chronic orthostatic intolerance. Can J Cardiol. 2020 Mar;36(3):357-72.
https://www.doi.org/10.1016/j.cjca.2019.12.024
http://www.ncbi.nlm.nih.gov/pubmed/32145864?tool=bestpractice.com