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Last reviewed: 22 Mar 2025
Last updated: 21 Jun 2023

Summary

Definition

History and exam

Key diagnostic factors

  • presence of risk factors
  • haematemesis

Other diagnostic factors

  • light-headedness/dizziness
  • postural/orthostatic hypotension
  • dysphagia
  • odynophagia
  • retrosternal, epigastric, or back pain
  • melaena
  • haematochezia
  • shock
  • signs of anaemia

Risk factors

  • condition predisposing to retching, vomiting, and/or straining
  • chronic cough
  • hiatal hernia
  • endoscopy or other instrumentation
  • heavy alcohol use
  • age 30 to 50 years
  • male sex
  • hiccups
  • blunt abdominal trauma
  • cardiopulmonary resuscitation

Diagnostic investigations

1st investigations to order

  • gastroscopy
  • full blood count
  • urea and creatinine
  • liver function tests
  • cross-matching/blood grouping

Investigations to consider

  • prothrombin time/international normalized ratio (PT/INR)
  • activated partial thromboplastin time (PTT)
  • chest x-ray
  • abdominal CT
  • CT angiogram

Treatment algorithm

Contributors

Expert advisers

Consultant Gastroenterologist

Site Lead of Gastrointestinal Medicine

Queen Elizabeth Hospital Birmingham

University Hospitals Birmingham

Edgbaston

Birmingham

UK

Disclosures

NB declares that he has no competing interests.

DBMJ Best Practice would like to gratefully acknowledge the previous expert contributor, whose work is retained in parts of the content:

Douglas G. Alder, MD, FACG, AGAF, FASGE

Professor of Medicine

Division of Gastroenterology

Department of Internal Medicine

Huntsman Cancer Institute

University of Utah

Salt Lake City

UT

Disclosures

DGA has consulted for Boston Scientific and Merit Medical, which make endoscopic retrograde cholangiopancreatography products.

Peer reviewers

Consultant Gastroenterologist

Clinical Associate Professor

Norwich Medical School

Department of Gastroenterology

Norfolk and Norwich University Hospital

Norwich

Norfolk

UK

Disclosures

IB declares that he has no competing interests.

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