Continuous rhythm monitoring is recommended until non-ST elevation myocardial infarction has been established or ruled out. Patients with unstable angina (troponin negative) without recurrent or ongoing symptoms and normal ECG can be monitored on a regular ward, but those with non-ST-elevation acute coronary syndrome should have rhythm monitoring.[1]Byrne RA, Rossello X, Coughlan JJ, et al. 2023 ESC guidelines for the management of acute coronary syndromes. Eur Heart J. 2023 Oct 12;44(38):3720-826.
https://academic.oup.com/eurheartj/article/44/38/3720/7243210
http://www.ncbi.nlm.nih.gov/pubmed/37622654?tool=bestpractice.com
Low-risk patients are defined by the absence of recurrent chest pain, ECG changes, serum cardiac markers, and findings of heart failure.[143]Schechtman KB, Capone RJ, Kleiger RE, et al. Risk stratification of patients with non-Q wave myocardial infarction: the critical role of ST segment depression - the Diltiazem Reinfarction Study Research Group. Circulation. 1989 Nov;80(5):1148-58.
http://www.ncbi.nlm.nih.gov/pubmed/2805257?tool=bestpractice.com
These patients should undergo non-invasive testing (using either exercise or pharmacological stress, and echo or nuclear imaging modalities) prior to hospital discharge and require aggressive risk factor modification.
Patients initially treated conservatively should be re-evaluated 2-6 weeks after discharge. They should be assessed for cardiac catheterisation and revascularisation, based on symptoms and non-invasive testing.[2]Amsterdam EA, Wenger NK, Brindis RG, et al. 2014 AHA/ACC guideline for the management of patients with non-ST-elevation acute coronary syndromes: a report of the American College of Cardiology/American Heart Association task force on practice guidelines. J Am Coll Cardiol. 2014 Dec 23;64(24):e139-228.
https://www.jacc.org/doi/full/10.1016/j.jacc.2014.09.017
http://www.ncbi.nlm.nih.gov/pubmed/25260718?tool=bestpractice.com
Clinicians caring for cardiac patients need to be aware of the high incidence of major depressive disorder in this population, and its association with worsened cardiovascular outcomes.[138]Frost JL, Rich RL Jr, Robbins CW, et al. Depression following acute coronary syndrome events: screening and treatment guidelines from the AAFP. Am Fam Physician. 2019 Jun 15;99(12).
https://www.aafp.org/pubs/afp/issues/2019/0615/odX.html
http://www.ncbi.nlm.nih.gov/pubmed/31194478?tool=bestpractice.com
[139]Jha MK, Qamar A, Vaduganathan M, et al. Screening and management of depression in patients with cardiovascular disease: JACC state-of-the-art review. J Am Coll Cardiol. 2019 Apr 16;73(14):1827-45.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7871437
http://www.ncbi.nlm.nih.gov/pubmed/30975301?tool=bestpractice.com
[144]Frasure-Smith N, Lesperance F, Talajic M. Depression and 18-month prognosis after myocardial infarction. Circulation. 1995 Feb 15;91(4):999-1005.
http://circ.ahajournals.org/content/91/4/999.full
http://www.ncbi.nlm.nih.gov/pubmed/7531624?tool=bestpractice.com
Accordingly, screening for symptoms of depression should be performed and therapy, including pharmacological, should be offered.[138]Frost JL, Rich RL Jr, Robbins CW, et al. Depression following acute coronary syndrome events: screening and treatment guidelines from the AAFP. Am Fam Physician. 2019 Jun 15;99(12).
https://www.aafp.org/pubs/afp/issues/2019/0615/odX.html
http://www.ncbi.nlm.nih.gov/pubmed/31194478?tool=bestpractice.com
[139]Jha MK, Qamar A, Vaduganathan M, et al. Screening and management of depression in patients with cardiovascular disease: JACC state-of-the-art review. J Am Coll Cardiol. 2019 Apr 16;73(14):1827-45.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7871437
http://www.ncbi.nlm.nih.gov/pubmed/30975301?tool=bestpractice.com
[145]Lichtman JH, Bigger JT Jr, Blumenthal JA, et al. Depression and coronary heart disease: recommendations for screening, referral, and treatment: a science advisory from the American Heart Association Prevention Committee of the Council on Cardiovascular Nursing, Council on Clinical Cardiology, Council on Epidemiology and Prevention, and Interdisciplinary Council on Quality of Care and Outcomes Research: endorsed by the American Psychiatric Association. Circulation. 2008 Oct 21;118(17):1768-75.
http://circ.ahajournals.org/content/118/17/1768.long
http://www.ncbi.nlm.nih.gov/pubmed/18824640?tool=bestpractice.com