Prognosis

Most cases of RVF resolve spontaneously and completely. However, sometimes fatigue and weakness persist for weeks or months.

Overall case fatality rates for patients with uncomplicated Rift Valley fever virus infection varies between epidemics; however, it is usually around 1%. For people who develop the haemorraghic form the case fatality is much higher at approximately 50%.[11]

Ocular complications can resolve spontaneously and completely within 10 to 12 weeks with no sequelae.[1][2][12][51] Ocular complications resulting from lesions in the macula can result in permanent vision loss and ocular damage in approximately 70% of patients.[1][32][35][53]

Neurological complications are associated with severe disease and may materialise up to 60 days after initial symptom onset. The spectrum of neurological complications extends from mild (intense headaches, disorientation) to severe (coma, memory loss). Residual neurological deficit and sequelae are common with severe complications. Supportive care can improve prognosis.[1][2][12][50]

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