Treatment algorithm
Please note that formulations/routes and doses may differ between drug names and brands, drug formularies, or locations. Treatment recommendations are specific to patient groups: see disclaimer
pregnant: susceptible to and exposed to rubella
specialist referral
Pregnant women with known exposure to rubella who are susceptible to rubella or who have uncertain immunity (no or unknown immunisation history and no previous serological testing), whether or not they are symptomatic, should be referred to a high-risk perinatal specialist and a paediatric infectious disease specialist to evaluate the likelihood of fetal infection and risk of sequelae.
intramuscular immunoglobulin
Additional treatment recommended for SOME patients in selected patient group
High dose polyclonal immunoglobulin may be of benefit for preventing clinical rubella but is not routinely recommended for this purpose because there is insufficient evidence for prevention of congenital rubella in the fetus.[48]Young MK, Cripps AW, Nimmo GR, et al. Post-exposure passive immunisation for preventing rubella and congenital rubella syndrome. Cochrane Database Syst Rev. 2015 Sep 9;(9):CD010586. https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010586.pub2/full http://www.ncbi.nlm.nih.gov/pubmed/26350479?tool=bestpractice.com This option may be considered for post-exposure prophylaxis.
Primary options
normal immunoglobulin human: 0.55 mL/kg intramuscularly as a single dose
non-pregnant: symptomatic rubella
supportive care
Postnatal rubella is generally a mild, self-limiting condition that requires only symptomatic therapy. No specific antiviral therapy is available. A brief course of an NSAID, if no contraindication exists, may be helpful for patients with arthritis.
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Please note that formulations/routes and doses may differ between drug names and brands, drug formularies, or locations. Treatment recommendations are specific to patient groups. See disclaimer
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