Cluster headache

Schindler EAD, Burish MJ. Recent advances in the diagnosis and management of cluster headache. BMJ. 2022 Mar 16;376:e059577. Abstract

Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018 Jan;38(1):1-211.Full text  Abstract

American College of Radiology. ACR appropriateness criteria: headache. 2022 [internet publication].Full text

Robbins MS, Starling AJ, Pringsheim TM, et al. Treatment of cluster headache: the American Headache Society evidence-based guidelines. Headache. 2016 Jul;56(7):1093-106.Full text  Abstract

Law S, Derry S, Moore RA. Triptans for acute cluster headache. Cochrane Database Syst Rev. 2013 Jul 17;(7):CD008042.Full text  Abstract

May A, Evers S, Goadsby PJ, et al. European Academy of Neurology guidelines on the treatment of cluster headache. Eur J Neurol. 2023 Oct;30(10):2955-79.Full text  Abstract

1. Schindler EAD, Burish MJ. Recent advances in the diagnosis and management of cluster headache. BMJ. 2022 Mar 16;376:e059577. Abstract

2. Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018 Jan;38(1):1-211.Full text  Abstract

3. Schurks M, Kurth T, de Jesus J, et al. Cluster headache: clinical presentation, lifestyle features, and medical treatment. Headache. 2006 Sep;46(8):1246-54. Abstract

4. Van Vliet JA, Eekers PJ, Haan J, et al. Features involved in the diagnostic delay of cluster headache. J Neurol Neurosurg Psychiatry. 2003 Aug;74(8):1123-5.Full text  Abstract

5. Wei DY, Yuan Ong JJ, Goadsby PJ. Cluster headache: epidemiology, pathophysiology, clinical features, and diagnosis. Ann Indian Acad Neurol. 2018 Apr;21(suppl 1):S3-S8.Full text  Abstract

6. Peng KP, Takizawa T, Lee MJ. Cluster headache in Asian populations: similarities, disparities, and a narrative review of the mechanisms of the chronic subtype. Cephalalgia. 2020 Sep;40(10):1104-12.Full text  Abstract

7. Bastos SNMAN, Barbosa BLF, Silva SF, et al. Cluster headache in children and adolescents: a systematic review of case reports. Dev Med Child Neurol. 2021 Oct;63(10):1155-60.Full text  Abstract

8. Elbadawi ASA, Albalawi AFA, Alghannami AK, et al. Cluster headache and associated risk factors: a systemic review and meta-analysis. Cureus. 2021 Nov;13(11):e19294.Full text  Abstract

9. May A. Cluster headache: pathogenesis, diagnosis, and management. Lancet. 2005 Sep 3-9;366(9488):843-55. Abstract

10. Barloese M. Current understanding of the chronobiology of cluster headache and the role of sleep in its management. Nat Sci Sleep. 2021 Feb 11;13:153-62.Full text  Abstract

11. Beck E, Sieber WJ, Trejo R. Management of cluster headache. Am Fam Physician. 2005 Feb 15;71(4):717-24.Full text  Abstract

12. Russell MB. Epidemiology and genetics of cluster headache. Lancet Neurol. 2004 May;3(5):279-83. Abstract

13. Gibson KF, Santos AD, Lund N, et al. Genetics of cluster headache. Cephalalgia. 2019 Sep;39(10):1298-312.Full text  Abstract

14. Silvestro M, Tessitore A, Orologio I, et al. Cluster headache pathophysiology: what we have learned from advanced neuroimaging. Headache. 2022 Apr;62(4):436-52.Full text  Abstract

15. Wei DY, Goadsby PJ. Cluster headache pathophysiology - insights from current and emerging treatments. Nat Rev Neurol. 2021 May;17(5):308-24. Abstract

16. Hoffmann J, May A. Diagnosis, pathophysiology, and management of cluster headache. Lancet Neurol. 2018 Jan;17(1):75-83. Abstract

17. Kudrow L. Physical and personality characteristics in cluster headache. Headache. 1974 Jan;13(4):197-202. Abstract

18. Rozen TD. Cluster headache clinical phenotypes: tobacco nonexposed (never smoker and no parental secondary smoke exposure as a child) versus tobacco-exposed: results from the United States Cluster Headache Survey. Headache. 2018 May;58(5):688-99. Abstract

19. de Coo IF, Wilbrink LA, Ie GD, et al. Aura in cluster headache: a cross-sectional study. Headache. 2018 Sep;58(8):1203-10.Full text  Abstract

20. Silberstein SD, Niknam R, Rozen TD, et al. Cluster headache with aura. Neurology. 2000 Jan 11;54(1):219-21. Abstract

21. American College of Radiology. ACR appropriateness criteria: headache. 2022 [internet publication].Full text

22. Mitsikostas DD, Ashina M, Craven A, et al. European Headache Federation consensus on technical investigation for primary headache disorders. J Headache Pain. 2015;17:5.Full text  Abstract

23. Long RJ, Zhu YS, Wang AP. Cluster headache due to structural lesions: a systematic review of published cases. World J Clin Cases. 2021 May 16;9(14):3294-307.Full text  Abstract

24. National Institute for Health and Care Excellence. Headaches in over 12s: diagnosis and management. Dec 2021 [internet publication].Full text

25. Brandt RB, Doesborg PGG, Haan J, et al. Pharmacotherapy for cluster headache. CNS Drugs. 2020 Feb;34(2):171-84.Full text  Abstract

26. Robbins MS, Starling AJ, Pringsheim TM, et al. Treatment of cluster headache: the American Headache Society evidence-based guidelines. Headache. 2016 Jul;56(7):1093-106.Full text  Abstract

27. Wang AL, Raven ML, Surapaneni K, et al. Studies on the histopathology of temporal arteritis. Ocul Oncol Pathol. 2017 Jan;3(1):60-5.Full text  Abstract

28. Law S, Derry S, Moore RA. Triptans for acute cluster headache. Cochrane Database Syst Rev. 2013 Jul 17;(7):CD008042.Full text  Abstract

29. Kwon JH, Han JY, Choi JW, et al. Comparative impact of pharmacological therapies on cluster headache management: a systematic review and network meta-analysis. J Clin Med. 2022 Mar 4;11(5):1411.Full text  Abstract

30. May A, Evers S, Goadsby PJ, et al. European Academy of Neurology guidelines on the treatment of cluster headache. Eur J Neurol. 2023 Oct;30(10):2955-79.Full text  Abstract

31. Cittadini E, May A, Straube A, et al. Effectiveness of intranasal zolmitriptan in acute cluster headache: a randomized, placebo-controlled, double-blind crossover study. Arch Neurol. 2006 Nov;63(11):1537-42.Full text  Abstract

32. Van Vliet JA, Bahra A, Martin V, et al. Intranasal sumatriptan in cluster headache: randomized placebo-controlled double-blind study. Neurology. 2003 Feb 25;60(4):630-3. Abstract

33. Bennett MH, French C, Schnabel A, et al. Normobaric and hyperbaric oxygen therapy for the treatment and prevention of migraine and cluster headache. Cochrane Database Syst Rev. 2015 Dec 28;(12):CD005219.Full text  Abstract

34. de Coo IF, Marin JC, Silberstein SD, et al. Differential efficacy of non-invasive vagus nerve stimulation for the acute treatment of episodic and chronic cluster headache: a meta-analysis. Cephalalgia. 2019 Jul;39(8):967-77.Full text  Abstract

35. National Institute for Health and Care Excellence. gammaCore for cluster headache. Dec 2019 [internet publication].Full text

36. Obermann M, Nägel S, Ose C, et al. Safety and efficacy of prednisone versus placebo in short-term prevention of episodic cluster headache: a multicentre, double-blind, randomised controlled trial. Lancet Neurol. 2021 Jan;20(1):29-37. Abstract

37. Leone M, D'Amico D, Frediani F, et al. Verapamil in the prophylaxis of episodic cluster headache: a double-blind study versus placebo. Neurology. 2000 Mar 28;54(6):1382-5. Abstract

38. Cohen AS, Matharu MS, Goadsby PJ. Electrocardiographic abnormalities in patients with cluster headache on verapamil therapy. Neurology. 2007 Aug 14;69(7):668-75. Abstract

39. Goadsby PJ, Dodick DW, Leone M, et al. Trial of galcanezumab in prevention of episodic cluster headache. N Engl J Med. 2019 Jul 11;381(2):132-41.Full text  Abstract

40. Dodick DW, Goadsby PJ, Lucas C, et al. Phase 3 randomized, placebo-controlled study of galcanezumab in patients with chronic cluster headache: results from 3-month double-blind treatment. Cephalalgia. 2020 Aug;40(9):935-48.Full text  Abstract

41. Ruscheweyh R, Broessner G, Goßrau G, et al. Effect of calcitonin gene-related peptide (-receptor) antibodies in chronic cluster headache: results from a retrospective case series support individual treatment attempts. Cephalalgia. 2020 Dec;40(14):1574-84.Full text  Abstract

42. Leone M, D'Amico D, Moschiano F, et al. Melatonin versus placebo in the prophylaxis of cluster headache: a double-blind pilot study with parallel groups. Cephalalgia. 1996 Nov;16(7):494-6. Abstract

43. Rozen TD. Cluster headache: diagnosis and treatment. Curr Pain Headache Rep. 2005 Apr;9(2):135-40. Abstract

44. Pack AM, Oskoui M, Williams Roberson S, et al. Teratogenesis, perinatal, and neurodevelopmental outcomes after in utero exposure to antiseizure medication: practice guideline from the AAN, AES, and SMFM. Neurology. 2024 Jun;102(11):e209279.Full text  Abstract

45. Medicines and Healthcare products Regulatory Agency​. Topiramate (topamax): introduction of new safety measures, including a pregnancy prevention programme. Jun 2024 [internet publication].Full text

46. European Medicines Agency. PRAC recommends new measures to avoid topiramate exposure in pregnancy. Sep 2023 [internet publication].Full text

47. Schuh-Hofer S, Israel H, Neeb L, et al. The use of gabapentin in chronic cluster headache patients refractory to first-line therapy. Eur J Neurol. 2007 Jun;14(6):694-6. Abstract

48. Gaul C, Diener HC, Silver N, et al. Non-invasive vagus nerve stimulation for PREVention and Acute treatment of chronic cluster headache (PREVA): a randomised controlled study. Cephalalgia. 2016 May;36(6):534-46.Full text  Abstract

49. Gaul C, Magis D, Liebler E, et al. Effects of non-invasive vagus nerve stimulation on attack frequency over time and expanded response rates in patients with chronic cluster headache: a post hoc analysis of the randomised, controlled PREVA study. J Headache Pain. 2017 Dec;18(1):22.Full text  Abstract

50. Medrea I, Christie S, Tepper SJ, et al. Effects of acute and preventive therapies for episodic and chronic cluster headache: a scoping review of the literature. Headache. 2022 Mar;62(3):329-62. Abstract

51. Donnet A, Valade D, Regis J. Gamma knife treatment for refractory cluster headache: prospective open trial. J Neurol Neurosurg Psychiatry. 2005 Feb;76(2):218-21.Full text  Abstract

52. Burns B, Watkins L, Goadsby PJ. Treatment of intractable chronic cluster headache by occipital nerve stimulation in 14 patients. Neurology. 2009 Jan 27;72(4):341-5. Abstract

53. Magis D, Gerardy PY, Remacle JM, et al. Sustained effectiveness of occipital nerve stimulation in drug-resistant chronic cluster headache. Headache. 2011 Sep;51(8):1191-201. Abstract

54. Burns B, Watkins L, Goadsby P. Treatment of medically intractable cluster headache by occipital nerve stimulation: long-term follow-up of 8 patients. Lancet. 2007 Mar 31;369(9567):1099-106. Abstract

55. Magis D, Allena M, Bolla M, et al. Occipital nerve stimulation for drug-resistant chronic cluster headache: a prospective pilot study. Lancet Neurol. 2007 Apr;6(4):314-21. Abstract

56. Leone M, Proietti Cecchini A, Messina G, et al. Long-term occipital nerve stimulation for drug-resistant chronic cluster headache. Cephalalgia. 2017 Jul;37(8):756-63. Abstract

57. Magis D, Gérard P, Schoenen J. Invasive occipital nerve stimulation for refractory chronic cluster headache: what evolution at long-term? Strengths and weaknesses of the method. J Headache Pain. 2016;17:8.Full text  Abstract

58. Schoenen J, Jensen RH, Lantéri-Minet M, et al. Stimulation of the sphenopalatine ganglion (SPG) for cluster headache treatment. Pathway CH-1: a randomized, sham-controlled study. Cephalalgia. 2013 Jul;33(10):816-30.Full text  Abstract

59. Jürgens TP, Barloese M, May A, et al. Long-term effectiveness of sphenopalatine ganglion stimulation for cluster headache. Cephalalgia. 2017 Apr;37(5):423-34.Full text  Abstract

60. Goadsby PJ, Sahai-Srivastava S, Kezirian EJ, et al. Safety and efficacy of sphenopalatine ganglion stimulation for chronic cluster headache: a double-blind, randomised controlled trial. Lancet Neurol. 2019 Dec;18(12):1081-90. Abstract

61. May A, Bahra A, Büchel C, et al. Hypothalamic activation in cluster headache attacks. Lancet. 1998 Jul 25;352(9124):275-8. Abstract

62. Leone M, Franzini A, Bussone G. Stereotactic stimulation of posterior hypothalamic grey matter in a patient with intractable cluster headache. N Engl J Med. 2001 Nov 8;345(19):1428-9.Full text  Abstract

63. Seijo F, Saiz A, Lozano B, et al. Neuromodulation of the posterolateral hypothalamus for the treatment of chronic refractory cluster headache: experience in five patients with a modified anatomical target. Cephalalgia. 2011 Dec;31(16):1634-41. Abstract

64. Leone M, Franzini A, Proietti Cecchini A, et al. Success, failure, and putative mechanisms in hypothalamic stimulation for drug-resistant chronic cluster headache. Pain. 2013 Jan;154(1):89-94. Abstract

65. Franzini A, Messina G, Cordella R, et al. Deep brain stimulation of the posteromedial hypothalamus: indications, long-term results, and neurophysiological considerations. Neurosurg Focus. 2010 Aug;29(2):E13.Full text  Abstract

66. Akram H, Miller S, Lagrata S, et al. Ventral tegmental area deep brain stimulation for refractory chronic cluster headache. Neurology. 2016 May 3;86(18):1676-82.Full text  Abstract

67. Ovadia C. Prescribing for pregnancy: managing chronic headache and migraine. Drug Ther Bull. 2021 Oct;59(10):152-6. Abstract

68. ACOG Committee on Clinical Practice Guidelines–Obstetrics. Headaches in pregnancy and postpartum: ACOG clinical practice guideline no. 3. Obstet Gynecol. 2022 May 1;139(5):944-72. Abstract

69. Marchenko A, Etwel F, Olutunfese O, et al. Pregnancy outcome following prenatal exposure to triptan medications: a meta-analysis. Headache. 2015 Apr;55(4):490-501. Abstract

70. Saldanha IJ, Cao W, Bhuma MR, et al. Management of primary headaches during pregnancy, postpartum, and breastfeeding: a systematic review. Headache. 2021 Jan;61(1):11-43. Abstract

71. Medicines and Healthcare products Regulatory Agency. Antiepileptic drugs in pregnancy: updated advice following comprehensive safety review. Jan 2021 [internet publication].Full text

72. Negro A, Delaruelle Z, Ivanova TA, et al. Headache and pregnancy: a systematic review. J Headache Pain. 2017 Oct 19;18(1):106.Full text  Abstract

73. McGeeney BE. Topiramate in the treatment of cluster headache. Curr Pain Headache Rep. 2003 Apr;7(2):135-8. Abstract

74. Herd CP, Tomlinson CL, Rick C, et al. Botulinum toxins for the prevention of migraine in adults. Cochrane Database Syst Rev. 2018 Jun 25;(6):CD011616.Full text  Abstract

75. Lenaerts ME, Green TH. OnabotulinumtoxinA in migraine and other headaches: review and update. Curr Treat Options Neurol. 2019 Apr 4;21(4):21. Abstract

76. Lampl C, Rudolph M, Bräutigam E. OnabotulinumtoxinA in the treatment of refractory chronic cluster headache. J Headache Pain. 2018 Jun 19;19(1):45.Full text  Abstract

77. ClinicalTrials.gov. Botulinum toxin type A blockade of the sphenopalatine ganglion in treatment-refractory chronic cluster headache (BASIC). Jan 2023 [internet publication].Full text

78. Schindler EA, Gottschalk CH, Weil MJ, et al. Indoleamine hallucinogens in cluster headache: results of the clusterbusters medication use survey. J Psychoactive Drugs. 2015 Nov-Dec;47(5):372-81. Abstract

79. ClinicalTrials.gov. Psilocybin for the treatment of cluster headache. Jul 2022 [internet publication].Full text

80. ClinicalTrials.gov. Eptinezumab in participants with episodic cluster headache (ALLEVIATE). Apr 2023 [internet publication].Full text