Emerging treatments
Botulinum toxin type A
Botulinum toxin type A has been found to be an effective preventative treatment for migraine.[74][75] There are several reports in the literature of botulinum toxin type A being promising in chronic cluster headache.[75][76] A randomised placebo-controlled study is under way.[77]
Psilocybin
Psilocybin is an indoleamine hallucinogen that has been used by some patients with cluster headache. Infrequent and non-hallucinogenic doses have been reported to be efficacious.[1][78] Clinical trials are under way.[79]
Other calcitonin gene-related peptide antagonists
Other monoclonal antibodies against calcitonin gene-related peptide are being investigated for cluster headache. A phase 3 trial of eptinezumab for prevention for episodic cluster headache is under way.[80] Phase 3 trials of fremanezumab were terminated early.[1]
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