Last reviewed: 18 Mar 2025
Last updated: 26 Apr 2022
Summary
Definition
History and exam
Key diagnostic factors
- presence of risk factors
- malodorous breath
- consumption of onions, garlic, or spiced food
- evidence of dental and/or periodontal disease
- evidence of disease of the oral mucosa
- evidence of nasopharyngeal disease
Other diagnostic factors
- evidence of upper respiratory tract or gastrointestinal disease
- evidence of upper respiratory tract and gastrointestinal malignancy
- evidence of endocrine, metabolic, hepatic, or renal disease
Risk factors
- oral disease
- respiratory disease
- gastrointestinal disease
- hepatic disease
- renal disease
- endocrine disease or hormonal changes
- metabolic disease
Diagnostic investigations
Investigations to consider
- sulfide monitor
- gas chromatography
- benzol-arginine-naphthylamide (BANA) test
- dark-field microscopy
- polymerase chain reaction of oral bacteria
- selected ion flow tube mass spectroscopy
Treatment algorithm
ACUTE
Contributors
Authors
Stephen R. Porter, BSc, PhD, MD, FDSRCS, FDSRCSEd, FHEA

Director and Professor of Oral Medicine
UCL Eastman Dental Institute
London
UK
Disclosures
SRP declares that he has no competing interests.
Stefano Fedele, DDS, PhD

Professor of Oral Medicine
UCL Eastman Dental Institute
London
UK
Disclosures
SF declares that he has no competing interests.
Peer reviewers
Giuseppina Campisi, DDS, PhD
Professor of Oral Medicine
Department of Oral Sciences
University of Palermo
Palermo
Italy
Disclosures
GC declares that she has no competing interests.
Ronald S. Brown, MD, DDS
Professor
Howard University College of Dentistry
Washington
DC
Disclosures
RSB declares that he has no competing interests.
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