Individual susceptibility to motion sickness appears to develop sometime during childhood, peak at around the age of puberty, and decline through adulthood.[10]Bronstein AM, Golding JF, Gresty MA. Visual vertigo, motion sickness, and disorientation in vehicles. Semin Neurol. 2020 Feb;40(1):116-29.
http://www.ncbi.nlm.nih.gov/pubmed/32045940?tool=bestpractice.com
[11]Keshavarz B, Golding JF. Motion sickness: current concepts and management. Curr Opin Neurol. 2022 Feb 1;35(1):107-12.
http://www.ncbi.nlm.nih.gov/pubmed/34839340?tool=bestpractice.com
Children aged 2-12 years are particularly susceptible to motion sickness, while older adults (aged >50 years) are less susceptible.[9]Centers for Disease Control and Prevention. CDC Yellow Book 2024: health information for international travel. Section 8: Travel by air, land & sea - motion sickness. May 2023 [internet publication].
https://wwwnc.cdc.gov/travel/yellowbook/2024/air-land-sea/motion-sickness
Actual vomiting appears to be infrequent beyond teenage years.[12]Turner M, Griffin MJ. Motion sickness in public road transport: passenger behavior and susceptibility. Ergonomics. 1999;42:444-461.
http://www.ncbi.nlm.nih.gov/pubmed/10048305?tool=bestpractice.com
There are wide variations in susceptibility to motion sickness, but only those individuals with a non-functional vestibular system are truly immune. In highly provocative environments, such as on a life raft in rough seas, all people can become motion sick.[1]Cha YH, Golding JF, Keshavarz B, et al. Motion sickness diagnostic criteria: consensus document of the Classification Committee of the Bárány Society. J Vestib Res. 2021;31(5):327-44.
https://content.iospress.com/articles/journal-of-vestibular-research/ves200005
http://www.ncbi.nlm.nih.gov/pubmed/33646187?tool=bestpractice.com
Although the impact of motion sickness on activities of daily life has not been surveyed extensively, about one third of people experience significant symptoms when riding in vehicles; with passenger illness occurrence three times higher for passengers with no view of the road ahead compared to passengers who could see the road ahead extremely well.[13]Flanagan MB, May JG, Dobie TG. Sex differences in tolerance to visually-induced motion sickness. Aviat Space Environ Med. 2005;76:642-46.
http://www.ncbi.nlm.nih.gov/pubmed/16018346?tool=bestpractice.com
In extreme cases of individuals with the highest levels of susceptibility, moderate motions may induce severe motion sickness that causes incapacitating malaise including nausea, dizziness, and headache, which may last throughout motion and for hours afterwards.
Women are more susceptible to motion sickness than men; women show a higher incidence of vomiting and report a higher incidence of symptoms such as nausea.[13]Flanagan MB, May JG, Dobie TG. Sex differences in tolerance to visually-induced motion sickness. Aviat Space Environ Med. 2005;76:642-46.
http://www.ncbi.nlm.nih.gov/pubmed/16018346?tool=bestpractice.com
[14]Kennedy RS, Lanham DS, Massey CJ, et al. Gender differences in simulator sickness incidence: implications for military virtual reality systems. Safe J. 1995;25:69-76.[15]Klosterhalfen S, Kellermann S, Pan F, et al. Effects of ethnicity and gender on motion sickness susceptibility. Aviat Space Environ Med. 2005;76:1051-1057.
http://www.ncbi.nlm.nih.gov/pubmed/16313141?tool=bestpractice.com
A 5:3 female-to-male risk ratio for vomiting has been shown for ferry passengers.[16]Lawther A, Griffin MJ. A survey of the occurrence of motion sickness amongst passengers at sea. Aviat Space Environ Med. 1988;59:399-406.
http://www.ncbi.nlm.nih.gov/pubmed/3390095?tool=bestpractice.com
There is evidence that there is a slightly higher susceptibility among people of Asian ancestry.[1]Cha YH, Golding JF, Keshavarz B, et al. Motion sickness diagnostic criteria: consensus document of the Classification Committee of the Bárány Society. J Vestib Res. 2021;31(5):327-44.
https://content.iospress.com/articles/journal-of-vestibular-research/ves200005
http://www.ncbi.nlm.nih.gov/pubmed/33646187?tool=bestpractice.com
[15]Klosterhalfen S, Kellermann S, Pan F, et al. Effects of ethnicity and gender on motion sickness susceptibility. Aviat Space Environ Med. 2005;76:1051-1057.
http://www.ncbi.nlm.nih.gov/pubmed/16313141?tool=bestpractice.com
[17]Stern RM, Hu S, LeBlanc R, et al. Chinese hyper-susceptibility to vection-induced motion sickness. Aviat Space Environ Med. 1993;64: 827-830.
http://www.ncbi.nlm.nih.gov/pubmed/8216144?tool=bestpractice.com
[18]Zhang LL, Wang JQ, Qi RR, et al. Motion sickness: current knowledge and recent advance. CNS Neurosci Ther. 2016 Jan;22(1):15-24.
http://www.ncbi.nlm.nih.gov/pubmed/26452639?tool=bestpractice.com