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Last reviewed: 16 Mar 2025
Last updated: 02 Jan 2025

Summary

Definition

History and exam

Key diagnostic factors

  • presence of risk factors
  • motion stimulus for symptoms
  • epigastric discomfort
  • nausea
  • headache
  • vomiting

Other diagnostic factors

  • cold sweating
  • dry mouth
  • dizziness
  • yawning and sleepiness
  • pallor
  • unsteadiness and incoordination

Risk factors

  • childhood age
  • female sex
  • Asian ancestry
  • family history of motion sickness
  • history of migraine
  • vestibulopathy
  • visual disorder
  • smoking
  • spatial disorientation and space-motion discomfort syndromes
  • hormonal factors
  • unpleasant odours/sight or smell of vomit
  • conflicting sensory inputs (e.g., reading in car, tilting trains)
  • psychological factors
  • spatially loaded concurrent tasks
  • neurological disorder

Diagnostic investigations

Treatment algorithm

Contributors

Authors

Amir Kheradmand, MD

Associate Professor

Department of Neurology, Neuroscience, Otolaryngology-Head and Neck Surgery, and Laboratory for Computational Sensing and Robotics (LCSR)

John Hopkins University School of Medicine

Baltimore

MD

Disclosures

AK is the author of references cited in this topic.

Qadeer Arshad, PhD

Associate Professor

inAmind Laboratory, College of Life Sciences

University of Leicester

Leicester

UK

Disclosures

QA is the author of references cited in this topic.

Acknowledgements

Dr Amir Kheradmand and Dr Qadeer Arshad would like to gratefully acknowledge Dr Kenneth L. Koch and Dr Michael A. Gresty, the previous contributors to this topic.

Disclosures

KLK and MAG are authors of several references cited in this topic.

Peer reviewers

Alan J. Benson, MB, ChB

Visiting Consultant to the Royal Air Force Centre for Aviation Medicine

Royal Air Force Henlow

UK

Disclosures

AJB declares that he has no competing interests.

David Andrew Green, PhD

Lecturer in Human Cardiorespiratory and Aerospace Physiology

Division of Applied Biomedical Research

Department of Physiology

King's College London

London

UK

Disclosures

DAG declares that he has no competing interests.

Michael von Brevern, MD, PhD

Department of Neurology

Park-Klinik Weissensee

Berlin

Germany

Disclosures

MVB declares that he has no competing interests.

Richard Lewis, MD

Associate Professor

Otolaryngology and Neurology

Harvard Medical School

Boston

MA

Disclosures

RL declares that he has no competing interests.

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