Summary
Definition
History and exam
Key diagnostic factors
- presence of risk factors
- low-grade fever
- oral vesicles and ulcers
- rash and/or vesicles on the hands and feet
Other diagnostic factors
- malaise
- sore mouth
- loss of appetite
- sore throat
- rash and/or vesicles on the buttocks
- abdominal pain
- diarrhoea
- cough
- tongue erythema/oedema
- arthralgia
Diagnostic investigations
Treatment algorithm
Contributors
Authors
Malobi I. Ogboli, MBBS, FRCP
Consultant Dermatologist
Birmingham Children's Hospital and Birmingham City Hospital
Birmingham
UK
Disclosures
MIO declares that she has no competing interests.
Peer reviewers
Helen Goodyear, MBChB, MRCP, FRCPCH, MD, MMed
Consultant Paediatrician
Heartlands Hospital
Birmingham
UK
Disclosures
HG declares that she has no competing interests.
Andrew Riordan, MD, FRCPCH, MRCP, DTM&H
Consultant in Paediatric Infectious Diseases and Immunology
Royal Liverpool Children's Hospital (Alder Hey)
Liverpool
UK
Disclosures
AR declares that he has no competing interests.
David Cassarino, MD, PhD
Assistant Professor
Department of Pathology and Laboratory Medicine
University of California
Los Angeles
CA
Disclosures
DC declares that he has no competing interests.
Leonid Izikson, MD
Staff Dermatologist
Department of Dermatology
Massachusetts General Hospital
Boston
MA
Disclosures
LI declares that he has no competing interests.
Aisha Sethi, MD
Assistant Professor of Medicine
Associate Residency Program Director
University of Chicago
Chicago
IL
Disclosures
AS declares that she has no competing interests.
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