Epidemiology
The infection usually occurs as a sporadic event, but outbreaks do occur worldwide. Coxsackievirus infection is extremely contagious. It affects males and females equally and is most common in children <10 years of age. However, infection in older children, adolescents, and adults can occur. Epidemics due to the more virulent strains of enterovirus 71 have occurred most often in East and South-east Asian countries such as Taiwan and Malaysia. These have resulted in severe illness with significant associated morbidity and mortality.[7][8][9][10][12][13]
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