Hand-foot-and-mouth disease

Spontaneous recovery with no complications is normal, and therefore follow-up is not usually required. However, infection with enterovirus 71, which occurs most often in East and South-east Asian countries, has caused more severe illness, with significant associated morbidity and mortality; one study from Taiwan found that 4% of patients had long-term sequelae, and death occurred in 8% of patients.[8]Chang LY, Huang LM, Gau SS, et al. Neurodevelopment and cognition in children after enterovirus 71 infection. N Engl J Med. 2007;356:1226-1234. http://www.nejm.org/doi/full/10.1056/NEJMoa065954#t=article http://www.ncbi.nlm.nih.gov/pubmed/17377160?tool=bestpractice.com