Tumor lysis syndrome

There are no data on prognosis of TLS following successful treatment or prevention.

Since the introduction of rasburicase, acute kidney injury requiring dialysis has been significantly reduced.[50]Patte C, Sakiroglu C, Ansoborlo S, et al. Urate-oxidase in the prevention and treatment of metabolic complications in patients with B-cell lymphoma and leukemia, treated in the Société Francaise d'Oncologie Pédiatrique LMB89 protocol. Ann Oncol. 2002 May;13(5):789-95. https://www.annalsofoncology.org/article/S0923-7534(19)62891-7/fulltext http://www.ncbi.nlm.nih.gov/pubmed/12075750?tool=bestpractice.com Increased understanding of the pathophysiology and awareness of TLS among physicians has led to improvements in management and outcomes.

The outcome and duration of inpatient stay may vary if complications such as cardiac arrhythmias, seizures, or acute kidney injury develop. Most of these complications can be successfully managed in large specialist centers.